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Titolo:
The evolutionary genetic underpinnings of schizophrenia: the developmentalinstability model
Autore:
Yeo, RA; Gangestad, SW; Edgar, C; Thoma, R;
Indirizzi:
Univ New Mexico, Dept Psychol, Albuquerque, NM 87131 USA Univ New Mexico Albuquerque NM USA 87131 ychol, Albuquerque, NM 87131 USA
Titolo Testata:
SCHIZOPHRENIA RESEARCH
fascicolo: 3, volume: 39, anno: 1999,
pagine: 197 - 206
SICI:
0920-9964(19991019)39:3<197:TEGUOS>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLANUM-TEMPORALE; CEREBRAL ASYMMETRY; HAND PREFERENCE; PSYCHOSIS; LANGUAGE; DYSLEXIA; ETIOLOGY; ORIGINS; HYPERACTIVITY; EPIDEMIOLOGY;
Keywords:
atypical cerebral lateralization; developmental instability; evolutionary genetics; neural development; schizophrenia; selection forces;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
77
Recensione:
Indirizzi per estratti:
Indirizzo: Yeo, RA Univ New Mexico, Dept Psychol, Albuquerque, NM 87131 USA Univ New Mexico Albuquerque NM USA 87131 lbuquerque, NM 87131 USA
Citazione:
R.A. Yeo et al., "The evolutionary genetic underpinnings of schizophrenia: the developmentalinstability model", SCHIZOPHR R, 39(3), 1999, pp. 197-206

Abstract

The importance of genes in the etiology of schizophrenia is well known, but the manner in which the relevant genomic factors influence neural development and the nature of selection forces operating on these factors are poorly understood. In several prominent papers, Crow has provided a unique and comprehensive theory that attempts to deal with these issues. A central aspect of his theory is that a single gene leads to reduced cerebral lateralization, increased ventricular size, and risk for developing schizophrenia. He relies greatly on Annett's right shift theory of individual variation in handedness. An alternative approach, based on the construct of developmental instability, provides a different way to conceptualize genetic influences, selection forces, and atypical lateralization in schizophrenia. We suggest that the developmental instability model has stronger empirical support and is better grounded in contemporary evolutionary genetics. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 01:17:00