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Titolo:
A lack of cerebral lateralization in schizophrenia is within the normal variation in brain maturation but indicates late, slow maturation
Autore:
Saugstad, LF;
Indirizzi:
Univ Oslo, Inst Basic Med Sci, Dept Anat, N-0317 Oslo, Norway Univ Oslo Oslo Norway N-0317 sic Med Sci, Dept Anat, N-0317 Oslo, Norway
Titolo Testata:
SCHIZOPHRENIA RESEARCH
fascicolo: 3, volume: 39, anno: 1999,
pagine: 183 - 196
SICI:
0920-9964(19991019)39:3<183:ALOCLI>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLANUM TEMPORALE ASYMMETRY; SEX-DIFFERENCES; DEVELOPMENTAL DYSLEXIA; CORTICAL DEVELOPMENT; ADULT SCHIZOPHRENIA; CHILDHOOD AUTISM; MENTAL-ILLNESS; FED INFANTS; SIZE; COGNITION;
Keywords:
brain maturation; cerebral lateralization; developmental dyslexia; handedness; infantile autism; multifactoral inheritance; optimal nutrition; planum temporale bias; schizophrenia;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
133
Recensione:
Indirizzi per estratti:
Indirizzo: Saugstad, LF Univ Oslo, Inst Basic Med Sci, Dept Anat, POB 1105 Blindern, N-0317 Oslo, Norway Univ Oslo POB 1105 Blindern Oslo Norway N-0317 Oslo, Norway
Citazione:
L.F. Saugstad, "A lack of cerebral lateralization in schizophrenia is within the normal variation in brain maturation but indicates late, slow maturation", SCHIZOPHR R, 39(3), 1999, pp. 183-196

Abstract

The planum temporale (PT) bias, PT leftward, PT symmetry, and PT rightwardreversal and sidedness preference, consistent right-handedness, ambilaterality, and consistent left-handedness are placed on a continuum mirroring the normal Variation in rate of brain maturation. Maturational rate declines as we pass from PT leftward bias and consistent right-handedness to PT reversal and consistent left-handedness. Concomitantly, we expect an increased prevalence of males due to their pubertal age being about 2 years later than that of females, and a shift in cognitive profile from higher Verbal scores than performance scores on the WAIS to higher performance than verbal scores. Three disorders fulfilling the criteria of late CNS maturation apart from the corresponding cognitive profile were studied: infantile autism (IA), schizophrenia (S), and developmental dyslexia (DD). These disorders have in common deficits in cognition, perception, and somatomotor function. The deficits range from an arrest in brain development (which is evident in infancysuperimposed on late maturation in IA) to overall delayed brain and somatic development in S (culminating in postpubertal psychotic episodes and persistent and generalized residual deficits). Finally, reading inability, problems in perception (vision and hearing) and in motor coordination, particularly between the two hemispheres, characterize DD. Enhancing brain maturation and the prevalence of 'normal' cerebral asymmetry-laterality is preferable if we want to reduce the risk of developing the above-mentioned disorders. It is suggested that in the past environmental challenges have favored early maturation, with its abundant neuronal population, arborization and excessive density of synapses and cerebral excitability which has powered evolution through the mechanism of natural selection. Early maturation is obtainable through optimal nutrition, including a satisfactory amount of marinefat (PUFA), before and during pregnancy and later in life. (C) 1999 Elsevier Science B.V. All rights reserved.

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Documento generato il 22/01/20 alle ore 13:20:53