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Titolo:
The theory of an agnosic right shift gene in schizophrenia and autism
Autore:
Annett, M;
Indirizzi:
Univ Leicester, Dept Psychol, Leicester LE1 7RH, Leics, England Univ Leicester Leicester Leics England LE1 7RH er LE1 7RH, Leics, England
Titolo Testata:
SCHIZOPHRENIA RESEARCH
fascicolo: 3, volume: 39, anno: 1999,
pagine: 177 - 182
SICI:
0920-9964(19991019)39:3<177:TTOAAR>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL LATERALIZATION; BIOLOGICAL MECHANISMS; PLANUM TEMPORALE; HAND SKILL; HYPOTHESIS; ASYMMETRY; ASSOCIATIONS; DOMINANCE; PATHOLOGY; PROGRAM;
Keywords:
agnosic mutant; autism; right shift theory; RS plus gene; schizophrenia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Annett, M Univ Leicester, Dept Psychol, Leicester LE1 7RH, Leics, England Univ Leicester Leicester Leics England LE1 7RH , Leics, England
Citazione:
M. Annett, "The theory of an agnosic right shift gene in schizophrenia and autism", SCHIZOPHR R, 39(3), 1999, pp. 177-182

Abstract

The right shift (RS) theory (Annett, M., 1972. The distribution of manual asymmetry. Pr. J. Psychol. 63, 343-358; Annett, M., 1985. Left, Right, Handand Brain: The Right Shift Theory. Lawrence Erlbaum, London) suggests thatthe typical pattern of human cerebral and manual asymmetries depends on a single gene (RS +) which impairs speech-related cortex of the right hemisphere. The theory offers solutions to several puzzles, including the distribution of handedness in families (Annett, M., 1978. A Single Gene Explanationof Right and Left Handedness and Brainedness. Lanchester Polytechnic, Coventry; Annett, M., 1996. In defense of the right shift theory. Percept. Motor Skills 82, 115-137), relations between handedness and cerebral speech laterality (Annett, M., 1975. Hand preference and the laterality of cerebral speech. Cortex 11, 305-328; Annett, M., Alexander, M.P., 1996. Atypical cerebral dominance: predictions and tests of the right shift theory. Neuropsychologia 34, 1215-1227) and handedness and dyslexia (Annett, M. et al., 1996. Types of dyslexia and the shift to dextrality. J. Child Psychol. Psychiatry 37, 167-180). If Crow's (Crow, T.J. et al., 1989. Schizophrenia as an anomaly of development of cerebral asymmetry. A postmortem study and a proposal concerning the genetic basis of the disease. Arch. Gen. Psychiatry 46, 1145-1150; Crow, T.J., 1997. Is schizophrenia the price that Homo sapiens pays for language? Schizophr. Res. 28, 127-141) theory that schizophrenia is due to an anomaly of cerebral dominance is correct, and if the RS theory is correct, schizophrenia could be due to an anomaly of the RS + gene. If the RS + gene were at risk for a mutation which caused a loss of directional coding, the mutant could be described as 'agnosic' for left and right. Such agene would impair either hemisphere at random. When paired with another RS+ gene, both hemispheres would be impaired in 50% of cases. The other 50% and people in whom the agnosic gene is paired with an RS-allele (neutral for asymmetry and not giving hemisphere impairment) would have one unaffectedhemisphere and, thus, normal development. Quantitative predictions based on the RS genetic theory as previously developed, plus an agnosic mutant with frequency required to give schizophrenia in 1% of the population, are consistent with estimates of concordance for schizophrenia in relatives. Homozygotes of the agnosic mutant would occur at about the rate estimated for autism. (C) 1999 Elsevier Science B.V. Ail rights reserved.

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Documento generato il 23/01/20 alle ore 03:22:56