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Titolo:
Comprehensive MR imaging protocol for stroke management: Tissue sodium concentration as a measure of tissue viability in nonhuman primate studies andin clinical studies
Autore:
Thulborn, KR; Gindin, TS; Davis, D; Erb, P;
Indirizzi:
Presbyterian Univ Hosp, MR Res Ctr, Pittsburgh, PA 15213 USA Presbyterian Univ Hosp Pittsburgh PA USA 15213 , Pittsburgh, PA 15213 USA
Titolo Testata:
RADIOLOGY
fascicolo: 1, volume: 213, anno: 1999,
pagine: 156 - 166
SICI:
0033-8419(199910)213:1<156:CMIPFS>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOCAL CEREBRAL-ISCHEMIA; MAGNETIC-RESONANCE; HUMAN-BRAIN; 1.5 T; STEADY-STATE; BLOOD-FLOW; RAT-BRAIN; CATS; THRESHOLDS; CONTRAST;
Keywords:
brain, infarction; brain, MR; magnetic resonance (MR), diffusion study; magnetic resonance (MR), perfusion study; magnetic resonance (MR), sodium studies; thrombolysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
69
Recensione:
Indirizzi per estratti:
Indirizzo: Thulborn, KR Presbyterian Univ Hosp, MR Res Ctr, B855,200 Lothrop St, Pittsburgh, PA 15213 USA Presbyterian Univ Hosp B855,200 Lothrop St Pittsburgh PA USA 15213
Citazione:
K.R. Thulborn et al., "Comprehensive MR imaging protocol for stroke management: Tissue sodium concentration as a measure of tissue viability in nonhuman primate studies andin clinical studies", RADIOLOGY, 213(1), 1999, pp. 156-166

Abstract

PURPOSE: To investigate sodium magnetic resonance (MR) imaging for monitoring tissue viability in stroke. MATERIALS AND METHODS: A comprehensive MR imaging protocol used to measureapparent diffusion coefficient and perfusion parameters was extended to include sodium imaging. Tissue sodium concentration was estimated by using a two-compartment model. This protocol lasted less than 45 minutes. These parameters were followed over the first 6 hours in a nonhuman primate model (n= 2) of acute embolic stroke without or with thrombolytic therapy. This protocol was used in patients in whom acute (<24 hours, n = 11) or nonacute (greater than or equal to 24 hours, n = 31) stroke was ultimately confirmed. RESULTS: The animal model showed abnormal diffusion and perfusion parameters in the lesion immediately after embolization, and these remained abnormal for over 6 hours. Tissue sodium concentration increased with time (5.7 mmol/L/h) unless halted with thrombolytic therapy. Regions with sodium concentrations over 70 mmol/L were histochemically verified as being infarcted. In patients in whom stroke older than 6 hours was clinically confirmed, sodium concentrations over 70 mmol/L were found in the appropriate brain regions. CONCLUSION: Tissue sodium concentration provides a sensitive measure of tissue viability that is complementary to the diagnostic role of diffusion and perfusion imaging for ischemic insult.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 04:48:07