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Titolo:
PET measurements of dopaminergic pathways in the brain
Autore:
Perlmutter, JS; Moerlein, SM;
Indirizzi:
Washington Univ, Sch Med, Dept Neurol & Neurol Surg, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 Neurol Surg, St Louis, MO 63110 USA Washington Univ, Sch Med, Dept Anat & Neurobiol, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 & Neurobiol, St Louis, MO 63110 USA Washington Univ, Sch Med, Dept Biochem & Mol Biophys, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 Mol Biophys, St Louis, MO 63110 USA Washington Univ, Sch Med, Mallinckrodt Inst Radiol, St Louis, MO 63110 USAWashington Univ St Louis MO USA 63110 Inst Radiol, St Louis, MO 63110 USA
Titolo Testata:
QUARTERLY JOURNAL OF NUCLEAR MEDICINE
fascicolo: 2, volume: 43, anno: 1999,
pagine: 140 - 154
SICI:
1125-0135(199906)43:2<140:PMODPI>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION-TOMOGRAPHY; CEREBRAL BLOOD-FLOW; D2-DOPAMINE RECEPTOR OCCUPANCY; LIVING HUMAN-BRAIN; STEADY-STATE MEASUREMENT; C-11 RACLOPRIDE BINDING; TIME UPTAKE DATA; F-18 DOPA PET; PARKINSONS-DISEASE; SCHIZOPHRENIC-PATIENTS;
Keywords:
tomography-emission computed; dopamine; neuropharmacology;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
153
Recensione:
Indirizzi per estratti:
Indirizzo: Perlmutter, JS Campus Box 8225,4525 Scott Ave, St Louis, MO 63110 USA Campus Box 8225,4525 Scott Ave St Louis MO USA 63110 0 USA
Citazione:
J.S. Perlmutter e S.M. Moerlein, "PET measurements of dopaminergic pathways in the brain", Q J NUCL M, 43(2), 1999, pp. 140-154

Abstract

Positron emission tomography (PET) measurements of dopaminergic pathways have revealed several new insights into the role of dopamine in the pathophysiology and pharmacology of brain diseases such as Parkinson's disease (PD), dystonia and schizophrenia. PET studies of regional blood now or metabolism identifies sites of regional pathology. Drug-induced changes in how or metabolism indicate the function of dopamine-mediated pathways. Measurementsof radioligand binding in vivo with PET reveals abnormalities associated with specific diseases and the actions of various drugs that affect the dopaminergic system. Finally, PET measurements of the uptake of analogues of levodopa provide clues to the function of dopamine pathways potentially important for diagnosis and treatment of disease like PD.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 12:37:39