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Titolo:
Age of onset of depression and quantitative neuroanatomic measures: absence of specific correlates
Autore:
Kumar, A; Bilker, W; Jin, ZS; Udupa, J; Gottlieb, G;
Indirizzi:
Univ Calif Los Angeles, Inst Neuropsychiat, Los Angeles, CA 90024 USA UnivCalif Los Angeles Los Angeles CA USA 90024 Los Angeles, CA 90024 USA Univ Penn, Dept Radiol, Philadelphia, PA 19104 USA Univ Penn PhiladelphiaPA USA 19104 pt Radiol, Philadelphia, PA 19104 USA Massachusetts Gen Hosp, Boston, MA 02114 USA Massachusetts Gen Hosp Boston MA USA 02114 Gen Hosp, Boston, MA 02114 USA
Titolo Testata:
PSYCHIATRY RESEARCH-NEUROIMAGING
fascicolo: 2, volume: 91, anno: 1999,
pagine: 101 - 110
SICI:
0925-4927(19990831)91:2<101:AOOODA>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
WHITE-MATTER LESIONS; LATE-LIFE; MAJOR DEPRESSION; GERIATRIC DEPRESSION; ELDERLY DEPRESSIVES; AFFECTIVE-DISORDER; DISTINCT SUBTYPE; BRAIN; MRI; DEFICITS;
Keywords:
late onset depression; age of onset; atrophy; geriatric depression; neuroanatomical abnormalities; magnetic resonance imaging; high intensity lesions;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Kumar, A Univ Calif Los Angeles, Inst Neuropsychiat, Room 37-384 B,760 Westwood Plaza, Los Angeles, CA 90024 USA Univ Calif Los Angeles Room 37-384 B,760 Westwood Plaza Los Angeles CA USA 90024
Citazione:
A. Kumar et al., "Age of onset of depression and quantitative neuroanatomic measures: absence of specific correlates", PSYCH RES-N, 91(2), 1999, pp. 101-110

Abstract

The purpose of our study was to examine the relationship between volumetric neuroanatomic measures and age of onset of illness in subjects with late-life major depression. Our sample was composed of 51 elderly subjects with Major Depressive Disorder who were scanned using a 1.5-tesla GE magnetic resonance imaging scanner with head coil. Absolute total and focal brain volumes were obtained together with quantified estimates of high intensity lesions. The relationship of these measures to onset age was examined using a regression while adjusting for subjects' current age and total intracranial volume. There was no significant linear relationship between age of onset of the first episode and any of the neuroanatomic measures examined. These data do not support the notion that neuroanatomical contributions to depression increase with a later age of onset of illness. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 18:16:50