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Titolo:
Quantitation of benzodiazepine receptor binding with PET [C-11]iomazenil and SPECT [I-123]iomazenil: preliminary results of a direct comparison in healthy human subjects
Autore:
Bremner, JD; Baldwin, R; Horti, A; Staib, LH; Ng, CK; Tan, PZ; Zea-Ponce, Y; Zoghbi, S; Seibyl, JP; Soufer, R; Charney, DS; Innis, RB;
Indirizzi:
VA Conn Healthcare Syst, Yale VA PET Ctr 115A, W Haven, CT 06516 USA VA Conn Healthcare Syst W Haven CT USA 06516 115A, W Haven, CT 06516 USA Yale Univ, Sch Med, Dept Diagnost Radiol, New Haven, CT 06520 USA Yale Univ New Haven CT USA 06520 Diagnost Radiol, New Haven, CT 06520 USA Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06520 USA Yale Univ New Haven CT USA 06520 , Dept Psychiat, New Haven, CT 06520 USA VA Connecticut Healthcare Syst, Psychiat Serv, W Haven, CT 06516 USA VA Connecticut Healthcare Syst W Haven CT USA 06516 W Haven, CT 06516 USA VA Connecticut Healthcare Syst, Natl Ctr PTSD, W Haven, CT 06516 USA VA Connecticut Healthcare Syst W Haven CT USA 06516 W Haven, CT 06516 USA
Titolo Testata:
PSYCHIATRY RESEARCH-NEUROIMAGING
fascicolo: 2, volume: 91, anno: 1999,
pagine: 79 - 91
SICI:
0925-4927(19990831)91:2<79:QOBRBW>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; HUMAN BRAIN; COMPUTED-TOMOGRAPHY; C-11 FLUMAZENIL; I-123 IOMAZENIL; IODINE-123-IOMAZENIL; KINETICS;
Keywords:
positron emission tomography; single photon emission computed tomography; benzodiazepine receptor binding; compartmental modeling; kinetic rate constants; methodology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Bremner, JD VA Conn Healthcare Syst, Yale VA PET Ctr 115A, 950 Campbell Ave, W Haven, CT 06516 USA VA Conn Healthcare Syst 950 Campbell Ave W Haven CT USA 06516
Citazione:
J.D. Bremner et al., "Quantitation of benzodiazepine receptor binding with PET [C-11]iomazenil and SPECT [I-123]iomazenil: preliminary results of a direct comparison in healthy human subjects", PSYCH RES-N, 91(2), 1999, pp. 79-91

Abstract

Although positron emission tomography (PET) and single photon emission computed tomography (SPECT) are increasingly used for quantitation of neuroreceptor binding, almost no studies to date have involved a direct comparison of the two. One study found a high level of agreement between the two techniques, although there was a systematic 30% increase in measures of benzodiazepine receptor binding in SPECT compared with PET. The purpose of the current study was to directly compare quantitation of benzodiazepine receptor binding in the same human subjects using PET and SPECT with high specific activity [C-11]iomazenil and [I-123]iomazenil, respectively. All subjects were administered a single bolus of high specific activity iomazenil labeled with C-11 or I-123 followed by dynamic PET or SPECT imaging of the brain. Arterial blood samples were obtained for measurement of metabolite-corrected radioligand in plasma. Compartmental modeling was used to fit values for kinetic rate constants of transfer of radioligand between plasma and brain compartments. These values were used for calculation of binding potential (BP= B-max/K-d) and product of BP and the fraction of free non-protein-bound parent compound (V3'). Mean values for V3' in PET and SPECT were as follows: temporal cortex 23 +/- 5 and 22 +/- 3 ml/g, frontal cortex 23 +/- 6 and 22 +/- 3 ml/g, occipital cortex 28 +/- 3 and 31 +/- 5 ml/g, and striatum 4 +/- 4 and 7 +/- 4 ml/g. These preliminary findings indicate that PET and SPECT provide comparable results in quantitation of neuroreceptor binding in the human brain. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 12:52:41