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Titolo:
Peripheral lymphocyte subsets and other immune aspects in Rett syndrome
Autore:
Fiumara, A; Sciotto, A; Barone, R; DAsero, G; Munda, S; Parano, E; Pavone, L;
Indirizzi:
Univ Catania, Dept Paediat Neurol, Catania, Italy Univ Catania Catania Italy Catania, Dept Paediat Neurol, Catania, Italy Univ Catania, Dept Paediat Haematol, Catania, Italy Univ Catania CataniaItaly tania, Dept Paediat Haematol, Catania, Italy Univ Catania, Paediat Clin, Catania, Italy Univ Catania Catania ItalyUniv Catania, Paediat Clin, Catania, Italy CNR, Ist Bioimmagini & Fisiopatol Sistema Nervoso Cent, Catania, Italy CNR Catania Italy ini & Fisiopatol Sistema Nervoso Cent, Catania, Italy
Titolo Testata:
PEDIATRIC NEUROLOGY
fascicolo: 3, volume: 21, anno: 1999,
pagine: 619 - 621
SICI:
0887-8994(199909)21:3<619:PLSAOI>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
10
Recensione:
Indirizzi per estratti:
Indirizzo: Fiumara, A Pediat Clin, Via S Sofia 78, I-95123 Catania, Italy Pediat ClinVia S Sofia 78 Catania Italy I-95123 atania, Italy
Citazione:
A. Fiumara et al., "Peripheral lymphocyte subsets and other immune aspects in Rett syndrome", PED NEUROL, 21(3), 1999, pp. 619-621

Abstract

A possible role of the immune system in the pathogenesis of some neurologic disorders, including infantile autism, was recently postulated, This observation prompted the authors to investigate some immunologic aspects in a group of patients with Rett syndrome, a disorder still not completely clarified but with some points of commonality with infantile autism. Humoral and cell-mediated immunity were investigated in 20 females with Rett syndrome. Peripheral lymphocyte subsets revealed a reduced percentage of CD8(+) suppressor-cytotoxic cells in all of the patients with Rett syndrome, resulting in an increased CD4(+)/CD8(+) ratio. In addition, 15 (75%) of the 20 patients had low levels of natural killer cells. Soluble interleukin-2 receptor was elevated in the youngest patients. Antineuronal and antimyelin ganglioside antibodies were absent, as were antinuclear antibodies, antistriated muscle antibodies, and antismooth muscle antibodies. Immunoglobulin fractions and complement were normal for age in all of the patients. (C) 1999 by Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 16:03:49