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Titolo:
Dehydroepiandrosterone replacement in women with adrenal insufficiency
Autore:
Arlt, W; Callies, F; van Vlijmen, JC; Koehler, I; Reincke, M; Bidlingmaier, M; Huebler, D; Oettel, M; Ernst, M; Schulte, HM; Allolio, B;
Indirizzi:
Med Univ Hosp, Dept Endocrinol, D-97080 Wurzburg, Germany Med Univ Hosp Wurzburg Germany D-97080 crinol, D-97080 Wurzburg, Germany Med Univ Hosp Innenstadt, Munich, Germany Med Univ Hosp Innenstadt Munich Germany osp Innenstadt, Munich, Germany Jenapharm, Jena, Germany Jenapharm Jena GermanyJenapharm, Jena, Germany Inst Hormone & Fertil Res, D-2000 Hamburg, Germany Inst Hormone & Fertil Res Hamburg Germany D-2000 D-2000 Hamburg, Germany
Titolo Testata:
NEW ENGLAND JOURNAL OF MEDICINE
fascicolo: 14, volume: 341, anno: 1999,
pagine: 1013 - 1020
SICI:
0028-4793(19990930)341:14<1013:DRIWWA>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSTMENOPAUSAL WOMEN; ORAL DEHYDROEPIANDROSTERONE; ANDROGEN REPLACEMENT; SEX-DIFFERENCES; DHEA; MEN; SULFATE; DEPRESSION; ESTROGENS; STEROIDS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Arlt, W Med Univ Hosp, Dept Endocrinol, Josef Schneider Str 2, D-97080 Wurzburg, Germany Med Univ Hosp Josef Schneider Str 2 Wurzburg Germany D-97080 many
Citazione:
W. Arlt et al., "Dehydroepiandrosterone replacement in women with adrenal insufficiency", N ENG J MED, 341(14), 1999, pp. 1013-1020

Abstract

Background The physiologic role of dehydroepiandrosterone in humans is still unclear. Adrenal insufficiency leads to a deficiency of dehydroepiandrosterone; we therefore investigated the effects of dehydroepiandrosterone replacement in patients with adrenal insufficiency. Methods In a double-blind study, 24 women with adrenal insufficiency received in random order 50 mg of dehydroepiandrosterone orally each morning forfour months and placebo daily for four months, with a one-month washout period. We measured serum steroid hormones, insulin-like growth factor I, lipids, and sex hormone-binding globulin, and we evaluated well-being and sexuality with the use of validated psychological questionnaires and visual-analogue scales, respectively. The women were assessed before treatment, afterone and four months of treatment with dehydroepiandrosterone, after one and four months of placebo, and one month after the end of the second treatment period. Results Treatment with dehydroepiandrosterone raised the initially low serum concentrations of dehydroepiandrosterone, dehydroepiandrosterone sulfate, androstenedione, and testosterone into the normal range; serum concentrations of sex hormone-binding globulin, total cholesterol, and high-density lipoprotein cholesterol decreased significantly. Dehydroepiandrosterone significantly improved overall well-being as well as scores for depression and anxiety. For the global severity index, the mean (+/-SD) change from base line was -0.18+/-0.29 after four months of dehydroepiandrosterone therapy, as compared with 0.03+/-0.29 after four months of placebo (P = 0.02). As compared with placebo, dehydroepiandrosterone significantly increased the frequency of sexual thoughts (P = 0.006), sexual interest (P = 0.002), and satisfaction with both mental and physical aspects of sexuality (P = 0.009 and P = 0.02, respectively). Conclusions Dehydroepiandrosterone improves well-being and sexuality in women with adrenal insufficiency. (N Engl J Med 1999;341:1013-20. ) (C)1999, Massachusetts Medical Society.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 00:47:40