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Titolo:
Calcitonin reverts pertussis toxin blockade of the opioid analgesia in mice
Autore:
Goicoechea, C; Ormazabal, MJ; Abalo, R; Alfaro, MJ; Martin, MI;
Indirizzi:
Univ Complutense Madrid, Fac Med, Dept Pharmacol, E-28040 Madrid, Spain Univ Complutense Madrid Madrid Spain E-28040 acol, E-28040 Madrid, Spain
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 3, volume: 273, anno: 1999,
pagine: 175 - 178
SICI:
0304-3940(19991008)273:3<175:CRPTBO>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT SPINAL-CORD; BETA-ENDORPHIN; INDUCED ANTINOCICEPTION; MYENTERIC PLEXUS; G-PROTEINS; PRETREATMENT; RELEASE; INHIBITION; RECEPTOR; AGONISTS;
Keywords:
calcitonin; pertussis toxin; opioids; analgesia; tail flick; mice;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Martin, MI Univ Complutense Madrid, Fac Med, Dept Pharmacol, E-28040 Madrid, Spain Univ Complutense Madrid Madrid Spain E-28040 40 Madrid, Spain
Citazione:
C. Goicoechea et al., "Calcitonin reverts pertussis toxin blockade of the opioid analgesia in mice", NEUROSCI L, 273(3), 1999, pp. 175-178

Abstract

The aim of this paper is to study the influence of salmon calcitonin (SCT)on opioid analgesia when opioid transduction pathways are functionally uncoupled from G(i/o) proteins by treatment with pertussis toxin (PTX). The antinociceptive effect of morphine and three selective opioid agonists, [D-Ala(2),N-Me-Phe(2),Gly(5)-ol]enkephalin (DAMGO) (OP3-mu receptor agonist), [D-Pen(2,5)]-enkephalin (OP1-delta receptor agonist) and trans-(+/-)-3,4-dichloro-N-methyl-N-[2-1(-pyrrolidinyl)-cyclohexyl]-benzene-acetamide methane sulfonate (U-50, 488H) (OP1-kappa receptor agonist) was evaluated, using thetail flick test, in mice treated with PTX or with PTX and SCT. PTX blockedthe antinociceptive effect of the opioids, being the antinociception similar in control animals and in mice treated with PTX and SCT. Thus, SCT prevents the effect of the blockade of G(i/o)-proteins. From this it could be suggested that calcitonin activates alternative antinociceptive mechanisms that are not dependent on G(i/o)-proteins. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 11:07:47