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Titolo:
Reduced dopamine in peripheral blood lymphocytes in Parkinson's disease
Autore:
Caronti, B; Tanda, G; Colosimo, C; Ruggieri, S; Calderaro, C; Palladini, G; Pontieri, FE; Di Chiara, G;
Indirizzi:
Univ La Sapienza, Dept Neurosci, I-00185 Rome, Italy Univ La Sapienza Rome Italy I-00185 , Dept Neurosci, I-00185 Rome, Italy Univ Cagliari, Dept Toxicol, I-09124 Cagliari, Italy Univ Cagliari Cagliari Italy I-09124 pt Toxicol, I-09124 Cagliari, Italy Univ Cagliari, CNR, Ctr Neuropharmacol, I-09124 Cagliari, Italy Univ Cagliari Cagliari Italy I-09124 opharmacol, I-09124 Cagliari, Italy INM Neuromed, I-86077 Pozzilli, IS, Italy INM Neuromed Pozzilli IS Italy I-86077 romed, I-86077 Pozzilli, IS, Italy
Titolo Testata:
NEUROREPORT
fascicolo: 14, volume: 10, anno: 1999,
pagine: 2907 - 2910
SICI:
0959-4965(19990929)10:14<2907:RDIPBL>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHAIN ENZYME-ACTIVITIES; LOCUS-COERULEUS; RECEPTOR GENE; NEUROPATHOLOGY; TRANSPORTERS; EXPRESSION; DIAGNOSIS; SPECT;
Keywords:
dopamine; Parkinson's disease; peripheral blood lymphocytes; tyrosine hydroxylase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Pontieri, FE Univ La Sapienza, Dept Neurosci, Viale Univ 30, I-00185 Rome,Italy Univ La Sapienza Viale Univ 30 Rome Italy I-00185 ome, Italy
Citazione:
B. Caronti et al., "Reduced dopamine in peripheral blood lymphocytes in Parkinson's disease", NEUROREPORT, 10(14), 1999, pp. 2907-2910

Abstract

THE early clinical symptoms of Parkinson's disease (PD) may-he difficult to perceive and are frequently overlooked. Thus, interest has focused on theidentification of biological or instrumental markers that may contribute to the early diagnosis of PD, with the aim of introducing neuroprotective therapies at the very start of:illness. Impairment of nigrostriatal dopamine transmission can he visualized in vivo by functional imaging techniques,:but these are rather complex and expensive examinations, available only in selected institutions. Here we show that dopamine content and tyrosine hydroxylase immunoreactivity are reduced in peripheral blood lymphocytes (PBL) inthe early stages of PD. These data suggest that PBL may represent a simpleand:useful tool with which to identify precociously dopamine impairment inPD. (C) 1999 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 09:26:34