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Titolo:
MK-801, and NMDA receptor antagonist, in the rostroventromedial medulla attenuates development of neuropathic symptoms in the rat
Autore:
Wei, H; Pertovaara, A;
Indirizzi:
Univ Helsinki, Inst Biomed, Dept Physiol, FIN-00014 Helsinki, Finland UnivHelsinki Helsinki Finland FIN-00014 ol, FIN-00014 Helsinki, Finland Univ Turku, Inst Biomed, Dept Physiol, FIN-20520 Turku, Finland Univ Turku Turku Finland FIN-20520 ept Physiol, FIN-20520 Turku, Finland
Titolo Testata:
NEUROREPORT
fascicolo: 14, volume: 10, anno: 1999,
pagine: 2933 - 2937
SICI:
0959-4965(19990929)10:14<2933:MANRAI>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
ROSTRAL VENTROMEDIAL MEDULLA; PERIPHERAL MONONEUROPATHY; VISCERAL HYPERALGESIA; NERVE; MAINTENANCE; ACTIVATION; INDUCTION; SYSTEMS;
Keywords:
MK-801; neuropathy; NMDA receptor antagonist; rostroventromedial medulla; pre-emptive analgesia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Pertovaara, A Univ Helsinki, Inst Biomed, Dept Physiol, POB 9, FIN-00014 Helsinki, Finland Univ Helsinki POB 9 Helsinki Finland FIN-00014 nki, Finland
Citazione:
H. Wei e A. Pertovaara, "MK-801, and NMDA receptor antagonist, in the rostroventromedial medulla attenuates development of neuropathic symptoms in the rat", NEUROREPORT, 10(14), 1999, pp. 2933-2937

Abstract

SEGMENTAL ligation of spinal nerves in the rat induces a long-lasting hyperalgesia and allodynia that mimicks neuropathic conditions in humans. In the present study we attempted to determine whether supraspinal NMDA receptors contribute to the induction of the long-lasting hypersensitivity to noxious and innocuous mechanical stimulation following segmental ligation of spinal nerves in the rat. MK-801, an NMDA receptor antagonist, was microinjected into the rostroventromedial medulla,(RVM) 15 min before or 25 min after the ligation of:spinal nerves and mechanical hypersensitivity was assessed at various time points following surgery by determining the hindlimb withdrawal threshold to noxious,and innocuous mechanical stimulation. A single dose of MK-801 administered prior to nerve ligation into the RVM significantly attenuated the development of mechanical hypersensitivity throughout the 2 week postoperative observation period, whereas corresponding administration of MK-801 immediately after-the nerve ligation attenuated the development of mechanical hypersensitivity only during the first postoperative day but not later. The results indicate that NMDA receptors in the RVM are involved in triggering the enhanced sensitivity to mechanical stimulation induced: by a nerve injury. (C) 1999 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 21:51:07