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Titolo:
Retention of supraspinal delta-like analgesia and loss of morphine tolerance in delta opioid receptor knockout mice
Autore:
Zhu, YX; King, MA; Schuller, AGP; Nitsche, JF; Reidl, M; Elde, RP; Unterwald, E; Pasternak, GW; Pintar, JE;
Indirizzi:
Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Neurosci & Cell Biol, Piscataway, NJ 08854 USA Univ Med & Dent New Jersey Piscataway NJ USA 08854 scataway, NJ 08854 USA Mem Sloan Kettering Canc Ctr, Dept Neurol, New York, NY 10021 USA Mem Sloan Kettering Canc Ctr New York NY USA 10021 New York, NY 10021 USA Univ Minnesota, Dept Cell Biol & Neuroanat, Minneapolis, MN 55455 USA UnivMinnesota Minneapolis MN USA 55455 roanat, Minneapolis, MN 55455 USA Temple Univ, Sch Med, Dept Pharmacol, Philadelphia, PA 19140 USA Temple Univ Philadelphia PA USA 19140 armacol, Philadelphia, PA 19140 USA
Titolo Testata:
NEURON
fascicolo: 1, volume: 24, anno: 1999,
pagine: 243 - 252
SICI:
0896-6273(199909)24:1<243:ROSDAA>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHARMACOLOGICAL CHARACTERIZATION; MESSENGER-RNA; EXPRESSION; DEPENDENCE; SUBTYPES; BINDING; MOUSE; ANTINOCICEPTION; NALTRINDOLE; WITHDRAWAL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Pintar, JE Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Neurosci & Cell Biol, Piscataway, NJ 08854 USA Univ Med & Dent New Jersey Piscataway NJ USA 08854 J 08854 USA
Citazione:
Y.X. Zhu et al., "Retention of supraspinal delta-like analgesia and loss of morphine tolerance in delta opioid receptor knockout mice", NEURON, 24(1), 1999, pp. 243-252

Abstract

Gene targeting was used to delete exon 2 of mouse DOR-1, which encodes thedelta opioid receptor. Essentially all 3H-[D-Pen(2),D-Pen(5)]enkephalin (H-3-DPDPE) and 3H-[D-Ala(2),D-Glu(4)]deltorphin (H-3-deltorphin-2) binding is absent from mutant mice, demonstrating that DOR-1 encodes both delta(1) and delta(2) receptor subtypes. Homozygous mutant mice display markedly reduced spinal 6 analgesia, but peptide 6 agonists retain supraspinal analgesicpotency that is only partially antagonized by naltrindole. Retained DPDPE analgesia is also demonstrated upon formalin testing, while the nonpeptide 6 agonist BW373U69 exhibits enhanced activity in DOR-l mutant mice. Together, these findings suggest the existence of a second delta-like analgesic system. Finally, DOR-1 mutant mice do not develop analgesic tolerance to morphine, genetically demonstrating a central role for DOR-1 in this process.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 21:49:52