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Titolo:
Protection against the bacterial mutagenicity of heterocyclic amines by purpurin, a natural anthraquinone pigment
Autore:
Marczylo, TH; Hayatsu, T; Arimoto-Kobayashi, S; Tada, M; Fujita, K; Kamataki, T; Nakayama, K; Hayatsu, H;
Indirizzi:
Okayama Univ, Fac Pharmaceut Sci, Okayama 7008530, Japan Okayama Univ Okayama Japan 7008530 harmaceut Sci, Okayama 7008530, Japan Okayama Univ, Fac Agr, Okayama 7008530, Japan Okayama Univ Okayama Japan7008530 Univ, Fac Agr, Okayama 7008530, Japan Hokkaido Univ, Fac Pharmaceut Sci, Lab Drug Metab, Sapporo, Hokkaido 0600812, Japan Hokkaido Univ Sapporo Hokkaido Japan 0600812 oro, Hokkaido 0600812, Japan
Titolo Testata:
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
fascicolo: 2, volume: 444, anno: 1999,
pagine: 451 - 461
SICI:
1383-5718(19990818)444:2<451:PATBMO>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
SALMONELLA-TYPHIMURIUM TA98; METABOLIC-ACTIVATION; RUBIA-TINCTORUM; AROMATIC-AMINES; TESTER STRAINS; DNA-BINDING; RAT-LIVER; FOOD; CHLOROPHYLLIN; CARCINOGENS;
Keywords:
purpurin; heterocyclic amine; Trp-P3; anti-mutagenesis; CYP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Marczylo, TH Okayama Univ, Fac Pharmaceut Sci, Tsushima Naka 1-1-1, Okayama 7008530, Japan Okayama Univ Tsushima Naka 1-1-1 Okayama Japan 7008530 Japan
Citazione:
T.H. Marczylo et al., "Protection against the bacterial mutagenicity of heterocyclic amines by purpurin, a natural anthraquinone pigment", MUT RES-GTE, 444(2), 1999, pp. 451-461

Abstract

Purpurin (1,2,4-trihydroxy-9,10-anthraquinone) is a naturally occurring anthraquinone pigment found in species of madder root. We have found that thepresence of purpurin in bacterial mutagenicity assays is responsible for amarked inhibition of mutagenicity induced by food-derived heterocyclic amines. Purpurin was found to be a better inhibitor of Trp-P-2-dependent mutagenicity than either epigallocatechin gallate or chlorophyllin both of whichare well-established anti-mutagenic components of diet. Inhibition of Trp-P-2(NHOH) mutagenicity by purpurin was dependent upon pH. It was a better inhibitor in neutral than acidic conditions. Purpurin was protective againstthe direct mutagen Trp-P-2(NHOH) in both the presence and the absence of hepatic S9 but required pre-incubation. Finally, purpurin was responsible for the inhibition of human CYP1A2 and human NADPH-cytochrome P450 reductase and a decrease in the bioactivation of Trp-P-2 by these enzymes when they were expressed in Salmonella typhimurium TA1538ARO. However, inhibition of Trp-P-2(NHOH)-dependent mutations suggests purpurin also has a direct effecton this mutagen in addition to inhibiting its formation by CYP1A2. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 02:20:16