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Titolo:
No clastogenic activity of a senna extract in the mouse micronucleus assay
Autore:
Mengs, U; Grimminger, W; Krumbiegel, G; Schuler, D; Silber, W; Volkner, W;
Indirizzi:
Madaus, D-51109 Cologne, Germany Madaus Cologne Germany D-51109Madaus, D-51109 Cologne, Germany Roha Arzneimittel, D-28355 Bremen, Germany Roha Arzneimittel Bremen Germany D-28355 mittel, D-28355 Bremen, Germany RCC Cytotest Cell Res, D-64380 Rossdorf, Germany RCC Cytotest Cell Res Rossdorf Germany D-64380 D-64380 Rossdorf, Germany
Titolo Testata:
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
fascicolo: 2, volume: 444, anno: 1999,
pagine: 421 - 426
SICI:
1383-5718(19990818)444:2<421:NCAOAS>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENOTOXICITY; CARCINOGENICITY; MUTAGENICITY; SENNOSIDES; CHRYSAZIN; DRUGS; MICE;
Keywords:
senna extract; anthraquinone; genotoxicity; micronucleus assay;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Mengs, U Madaus, Ostmerheimer Str 198, D-51109 Cologne, Germany Madaus Ostmerheimer Str 198 Cologne Germany D-51109 gne, Germany
Citazione:
U. Mengs et al., "No clastogenic activity of a senna extract in the mouse micronucleus assay", MUT RES-GTE, 444(2), 1999, pp. 421-426

Abstract

In previous studies, an analytically well-defined senna extract, commonly used as a laxative, gave positive responses in vitro in the Ames test and in the CHO assay. Therefore, the objective of this study was to investigate the genotoxic activity of the same senna extract in an in vivo genotoxicityassay by means of the generally acknowledged MNT. After administration of an oral dose of 2000 mg senna extract/kg to NMRI mice of both genders, which is equivalent to 119 mg potential (1) rhein/kg, 5.74 mg potential aloeemodin/kg and 0.28 mg potential emodin/kg, there were no elevated levels of micronuclei in bone marrow cells. Kinetic studies were performed in parallel to demonstrate target organ availability. Highest concentrations in the plasma were reached after 1 h with 3.4 mu g rhein/ml and 0.065 mu g aloeemodin/ml. In all cases, emodin was below the limit of quantification. From the results, the in vitro clastogenic activity of the senna extract could not beconfirmed in the mouse micronucleus assay. Together with further negative in vivo genotoxicity studies with anthranoids, the conclusion can be drawn that there is no indication so far demonstrating a genotoxic risk for patients taking senna laxatives. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 13:23:34