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Titolo:
Mutagenicity of 4-nitroquinoline 1-oxide in the Muta (TM) Mouse
Autore:
Nakajima, M; Kikuchi, M; Saeki, K; Miyata, Y; Terada, M; Kishida, F; Yamamoto, R; Furihata, C; Dean, SW;
Indirizzi:
Food Drug & Pesticide, Biosafety Res Ctr, Fukude, Shizuoka 4371213, Japan Food Drug & Pesticide Fukude Shizuoka Japan 4371213 izuoka 4371213, Japan Nagoya City Univ, Fac Pharmaceut Sci, Mizuho Ku, Aichi 4670027, Japan Nagoya City Univ Aichi Japan 4670027 ci, Mizuho Ku, Aichi 4670027, Japan Kumiai Chem, Kikugawa, Shizuoka 4390031, Japan Kumiai Chem Kikugawa Shizuoka Japan 4390031 gawa, Shizuoka 4390031, Japan Sumitomo Chem Co Ltd, Konohana Ku, Osaka 5540022, Japan Sumitomo Chem Co Ltd Osaka Japan 5540022 nohana Ku, Osaka 5540022, Japan Univ Tokyo, Inst Med Sci, Minato Ku, Tokyo 1080071, Japan Univ Tokyo Tokyo Japan 1080071 Med Sci, Minato Ku, Tokyo 1080071, Japan Covance Labs, Harrogate HG3 1PY, N Yorkshire, England Covance Labs Harrogate N Yorkshire England HG3 1PY , N Yorkshire, England
Titolo Testata:
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
fascicolo: 2, volume: 444, anno: 1999,
pagine: 321 - 336
SICI:
1383-5718(19990818)444:2<321:MO41IT>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
MICE; CARCINOGENS; INVIVO; MOUSE; DNA;
Keywords:
transgenic mouse; lacZ; 4-nitroquinoline 1-oxide;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Nakajima, M Food Drug & Pesticide, Biosafety Res Ctr, 582-2 Shioshinden, Fukude, Shizuoka 4371213, Japan Food Drug & Pesticide 582-2 Shioshinden Fukude Shizuoka Japan 4371213
Citazione:
M. Nakajima et al., "Mutagenicity of 4-nitroquinoline 1-oxide in the Muta (TM) Mouse", MUT RES-GTE, 444(2), 1999, pp. 321-336

Abstract

As part of a collaborative study, the Mammalian Mutagenesis Study Group (MMS), a sub-organization of the Environmental Mutagen Society of Japan (JEMS) conducted mutagenicity tests in Muta(TM)Mouse. Using a positive selectionmethod, we studied the organ-specificity and time dependence of mutation induction by 4-nitroquinoline 1-oxide (4NQO). A single dose of 4NQO was administered intraperitoneally (7.5 or 15 mg/kg) or orally (200 mg/kg) to groups of male mice. On days 7, 14 and 28 after treatment, we isolated the liver, kidney, lung, spleen, bone marrow, testis and stomach in the intraperitoneal administration experiment and the liver, lung, bone marrow, testis and stomach in the oral administration experiment. In addition, we performed the peripheral blood micronucleus test to evaluate clastogenicity. In the mice treated intraperitoneally at 7.5 mg/kg, we found increased mutant frequency (MF) only in the lung, where the MF did not vary with expression time. In the mice treated at 15 mg/kg, we found increased MF in the liver, bone marrow and lung. In orally treated mice, the MF was high in the lung and liver and very high in the bone marrow and stomach while the increase in the testis was negligible. As the expression time was prolonged, the MF tended toincrease in the liver, decrease in the bone marrow, and remain stable in the lung, testis and stomach. The incidence of micronucleus induction in peripheral blood cells was significantly increased (p < 0.01) in the 4NQO groups when compared with the vehicle control group by intraperitoneal treatment. Thus, these assay systems appeared to be of use in detecting not only genetic mutation but also chromosomal aberration. (C) 1999 Elsevier Science B. V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 20:30:10