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Titolo:
Identification of the major intestinal fatty acid transport protein
Autore:
Stahl, A; Hirsch, DJ; Gimeno, RE; Punreddy, S; Ge, P; Watson, N; Patel, S; Kotler, M; Raimondi, A; Tartaglia, LA; Lodish, HF;
Indirizzi:
Whitehead Inst Biomed Res, Cambridge, MA 02142 USA Whitehead Inst Biomed Res Cambridge MA USA 02142 Cambridge, MA 02142 USA MIT, Dept Biol, Cambridge, MA 02139 USA MIT Cambridge MA USA 02139MIT, Dept Biol, Cambridge, MA 02139 USA Millennium Pharmaceut Inc, Cambridge, MA 02139 USA Millennium Pharmaceut Inc Cambridge MA USA 02139 Cambridge, MA 02139 USA
Titolo Testata:
MOLECULAR CELL
fascicolo: 3, volume: 4, anno: 1999,
pagine: 299 - 308
SICI:
1097-2765(199909)4:3<299:IOTMIF>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
BINDING-PROTEIN; EXPRESSION CLONING; MEMBRANE-PROTEIN; DIETARY-FAT; RAT-LIVER; ABSORPTION; THERAPEUTICS; ENTEROCYTES; MECHANISMS; DIGESTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Lodish, HF Whitehead Inst Biomed Res, 9 Cambridge Ctr, Cambridge, MA 02142USA Whitehead Inst Biomed Res 9 Cambridge Ctr Cambridge MA USA 02142
Citazione:
A. Stahl et al., "Identification of the major intestinal fatty acid transport protein", MOL CELL, 4(3), 1999, pp. 299-308

Abstract

While intestinal transport systems for metabolites such as carbohydrates have been well characterized, the molecular mechanisms of fatty acid (FA) transport across the apical plasmalemma of enterocytes have remained largely unclear. Here, we show that FATP4 a member of a large family of FA transport proteins (FATPs), is expressed at high levels on the apical side of mature enterocytes in the small intestine. Further, overexpression of FATP4 in 293 cells facilitates uptake of long chain FAs with the same specificity as enterocytes, while reduction of FATP4 expression in primary enterocytes by antisense oligonucleotides inhibits FA uptake by 50%. This suggests that FATP4 is the principal fatty acid transporter in enterocytes and may constitute a novel target for antiobesity therapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 10:19:19