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Titolo:
Is flow cytometric DNA content hypodiploidy prognostic in multiple myeloma?
Autore:
Greipp, PR; Trendle, MC; Leong, T; Oken, MM; Kay, NE; Van Ness, B; Kyle, RA;
Indirizzi:
Mayo Clin & Mayo Fdn, Div Hematol, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn Rochester MN USA 55905 atol, Rochester, MN 55905 USA
Titolo Testata:
LEUKEMIA & LYMPHOMA
fascicolo: 1-2, volume: 35, anno: 1999,
pagine: 83 - 89
SICI:
1042-8194(199909)35:1-2<83:IFCDCH>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMA-CELL LEUKEMIA; LABELING INDEXES; CANCER; PLOIDY;
Keywords:
multiple myeloma; flow cytometry; ploidy; hypodiploid;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Greipp, PR Mayo Clin & Mayo Fdn, Div Hematol, 920 Hilton,200 1st Ave SW, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn 920 Hilton,200 1st Ave SW Rochester MN USA 55905
Citazione:
P.R. Greipp et al., "Is flow cytometric DNA content hypodiploidy prognostic in multiple myeloma?", LEUK LYMPH, 35(1-2), 1999, pp. 83-89

Abstract

Hypodiploid multiple myeloma is uncommon when assessed by DNA content flowcytometry, having been reported in less than 6% of patients with newly diagnosed multiple myeloma. Previous studies have shown these patients to be unresponsive to therapy and to have short survival. To address this further,we studied 349 of 504 patients eligible for Eastern Cooperative Oncology Group (ECOG) treatment trial E9486 and laboratory correlative study E9487 who had marrow mononuclear cells available for ploidy analysis. Marrow samples were studied by dual channel flow cytometry, using propidium iodide to measure the DNA content and kappa and lambda light chain antisera to identifythe clonal cells. A DNA index < 0.95 was considered hypodiploid. Five patients (1.4%) were found to have hypodiploid DNA content in their marrow plasma cells. Three of the 5 patients with hypodiploid myeloma had a partial objective response to chemotherapy, which is not different from the overall objective response rate for all patients enrolled on E9486. All five patients with hypodiploid multiple myeloma died within 4 years from diagnosis, butthese patients had a similar overall median survival (2.6 years) compared to the patients with diploid DNA content. Our studies confirm the poorer survival of patients with diploid versus hyperdiploid myeloma; we cannot confirm, however, the previously reported very poor outcome associated with hypodiploid myeloma using DNA content flow cytometry. Hypodiploid DNA content of plasma cells by flow cytometry may not be as ominous a factor as previously reported.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 18:59:30