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Titolo:
New cytotoxic polyacetylenes from the marine sponge Petrosia
Autore:
Lim, YJ; Kim, JS; Im, KS; Jung, JH; Lee, CO; Hong, J; Kim, D;
Indirizzi:
Pusan Natl Univ, Coll Pharm, Pusan 609735, South Korea Pusan Natl Univ Pusan South Korea 609735 harm, Pusan 609735, South Korea Korea Res Inst Chem Technol, Taejon 305606, South Korea Korea Res Inst Chem Technol Taejon South Korea 305606 05606, South Korea Korea Basic Sci Inst, Taejon, South Korea Korea Basic Sci Inst Taejon South Korea c Sci Inst, Taejon, South Korea Inje Univ, Dept Chem, Kimhae, South Korea Inje Univ Kimhae South KoreaInje Univ, Dept Chem, Kimhae, South Korea
Titolo Testata:
JOURNAL OF NATURAL PRODUCTS
fascicolo: 9, volume: 62, anno: 1999,
pagine: 1215 - 1217
SICI:
0163-3864(199909)62:9<1215:NCPFTM>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
FATTY-ACIDS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
7
Recensione:
Indirizzi per estratti:
Indirizzo: Jung, JH Pusan Natl Univ, Coll Pharm, Pusan 609735, South Korea Pusan NatlUniv Pusan South Korea 609735 an 609735, South Korea
Citazione:
Y.J. Lim et al., "New cytotoxic polyacetylenes from the marine sponge Petrosia", J NAT PROD, 62(9), 1999, pp. 1215-1217

Abstract

New polyacetylenic alcohols with a C-45 carbon skeleton (2) and with an enone moiety in the alkyl chain (C-46, 1) were isolated from the marine sponge Petrosia sp. The gross structures of 1 and 2 were established by spectralmethods, and the absolute stereochemistry was determined by-the modified Mosher's method. Compounds 1 and 2 displayed considerable cytotoxicity against a small panel of human solid tumor cell lines. Significant inhibitions on DNA replication by 1 and 2 were also observed which could be explanative of their cytotoxicity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 10:57:53