Catalogo Articoli (Spogli Riviste)

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Titolo:
Extracorporeal support and hepatocyte transplantation in acute liver failure and cirrhosis
Autore:
Riordan, SM; Williams, R;
Indirizzi:
Royal Free & Univ Coll, Sch Med, Inst Hepatol, London WC1E 6HX, England Royal Free & Univ Coll London England WC1E 6HX London WC1E 6HX, England Univ Coll London Hosp, London, England Univ Coll London Hosp London England Coll London Hosp, London, England
Titolo Testata:
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
fascicolo: 8, volume: 14, anno: 1999,
pagine: 757 - 770
SICI:
0815-9319(199908)14:8<757:ESAHTI>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
FULMINANT HEPATIC-FAILURE; CONDITIONALLY IMMORTALIZED HEPATOCYTES; MICROCARRIER-ATTACHED HEPATOCYTES; T-ANTIGEN GENE; BIOARTIFICIAL LIVER; CHARCOAL HEMOPERFUSION; RAT HEPATOCYTES; ASSIST DEVICE; CLINICAL-EXPERIENCE; ARTIFICIAL LIVER;
Keywords:
acute liver failure; extracorporeal support; hepatocyte transplantation;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
163
Recensione:
Indirizzi per estratti:
Indirizzo: Williams, R Royal Free & Univ Coll, Sch Med, Inst Hepatol, 69-75 Chenies Mews, London WC1E 6HX, England Royal Free & Univ Coll 69-75 Chenies Mews London England WC1E 6HX
Citazione:
S.M. Riordan e R. Williams, "Extracorporeal support and hepatocyte transplantation in acute liver failure and cirrhosis", J GASTR HEP, 14(8), 1999, pp. 757-770

Abstract

The relative shortage of donor organs and lack of immediate availability mean that many patients with acute liver failure die before orthotopic livertransplantation can be performed. An effective temporary liver support system could improve the chance of survival with or without a transplant beingultimately carried out. Recent technological advances resulting in improved maintenance of hepatocyte viability and function in culture and bioreactor designs which facilitate adequate perfusion of the cellular component andremoval of products of cellular metabolism have led to the development of a number of bioartificial devices for liver support. Three such devices have undergone preliminary clinical evaluation in the setting of acute liver failure, with a statistically significant reduction in raised intracerebral pressure along with improvements in consciousness level and some biochemical parameters associated with treatment with one of these. Several other devices with different characteristics have shown promise in vitro and/or in animal models but await clinical evaluation. Several new totally artificial systems have also been described, along with the emergence of isolated hepatocyte transplantation, with reports of successful 'bridging' to liver transplantation. Controlled trials on a multicentre basis in well-defined patient groups and with standardized outcome measures will be required to properly evaluate the clinical Value of each of these approaches to providing liver support in acute liver failure and cirrhosis. A better understanding of mechanisms underlying multiorgan failure and of factors inhibiting liver regeneration, thereby allowing a more targeted approach, will be essential tothe further development of effective liver support strategies in these settings. (C) 1999 Blackwell Science Asia Pty Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/21 alle ore 14:59:53