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Titolo:
Chemopreventive potential of neem (Azadirachta indica) on 7,12-dimethylbenz[a]anthracene (DMBA) induced hamster buccal pouch carcinogenesis
Autore:
Balasenthil, S; Arivazhagan, S; Ramachandran, CR; Ramachandran, V; Nagini, S;
Indirizzi:
Annamalai Univ, Fac Sci, Dept Biochem, Annamalainagar 608002, Tamil Nadu, India Annamalai Univ Annamalainagar Tamil Nadu India 608002 , Tamil Nadu, India Annamalai Univ, Fac Dent, Dept Oral Pathol, Annamalainagar 608002, Tamil Nadu, India Annamalai Univ Annamalainagar Tamil Nadu India 608002 , Tamil Nadu, India Annamalai Univ, Fac Sci, Dept Stat, Annamalainagar 608002, Tamil Nadu, India Annamalai Univ Annamalainagar Tamil Nadu India 608002 , Tamil Nadu, India
Titolo Testata:
JOURNAL OF ETHNOPHARMACOLOGY
fascicolo: 2, volume: 67, anno: 1999,
pagine: 189 - 195
SICI:
0378-8741(199911)67:2<189:CPON(I>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
CANCER CHEMOPREVENTION; PLANT-PRODUCTS; GLUTATHIONE; AGENTS; TRANSFERASES;
Keywords:
oral cancer; neem; chemoprevention; lipid peroxidation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Nagini, S Annamalai Univ, Fac Sci, Dept Biochem, Annamalainagar 608002, Tamil Nadu, India Annamalai Univ Annamalainagar Tamil Nadu India 608002 du, India
Citazione:
S. Balasenthil et al., "Chemopreventive potential of neem (Azadirachta indica) on 7,12-dimethylbenz[a]anthracene (DMBA) induced hamster buccal pouch carcinogenesis", J ETHNOPHAR, 67(2), 1999, pp. 189-195

Abstract

The inhibitory effect of the aqueous extract of neem (Azadirachta indica A. Juss.) on 7,12-dimethylbenz[a]anthracene (DMBA) induced buccal pouch carcinogenesis was investigated in Syrian male hamsters. All hamsters painted on their buccal pouch with DMBA for 14 weeks developed squamous cell carcinoma. Administration of neem leaf extract effectively suppressed oral carcinogenesis initiated with DMBA as revealed by the reduced incidence of neoplasms. Lipid peroxidation, glutathione (GSH) content and the activities of glutathione peroxidase (GPx), glutathione S-transferase (GST) and gammaglutamyl transpeptidase (GGT) were used to biomonitor the chemopreventive potential of neem. Lipid peroxidation was found to be significantly decreased, whereas GSH, GPx, GST and GGT were elevated in the oral mucosa of tumour bearing animals. Our data suggest that neem may exert its chemopreventive effectsin the oral mucosa by modulation of lipid peroxidation, antioxidants and detoxification systems. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 10:32:20