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Titolo:
Rapid imaging of olfaction by functional MRI (fMRI): Identification of presence and type of hyposmia
Autore:
Levy, LM; Henkin, RI; Lin, CS; Finley, A;
Indirizzi:
Taste & Smell Clin, Washington, DC 20016 USA Taste & Smell Clin Washington DC USA 20016 Clin, Washington, DC 20016 USA Georgetown Univ, Med Ctr, Washington, DC 20007 USA Georgetown Univ Washington DC USA 20007 Med Ctr, Washington, DC 20007 USA
Titolo Testata:
JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY
fascicolo: 5, volume: 23, anno: 1999,
pagine: 767 - 775
SICI:
0363-8715(199909/10)23:5<767:RIOOBF>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN BRAIN; ORBITOFRONTAL CORTEX; MONKEY; ASSOCIATIONS; CONNECTIONS; STIMULATION; RECOGNITION; ACTIVATION; DEFICITS; REGIONS;
Keywords:
magnetic resonance imaging, functional (fMRI); hyposmia; brain, anatomy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Henkin, RI Taste & Smell Clin, 5125 MacArthur Blvd NW,Suite 20, Washington, DC 20016 USA Taste & Smell Clin 5125 MacArthur Blvd NW,Suite 20 Washington DC USA 20016
Citazione:
L.M. Levy et al., "Rapid imaging of olfaction by functional MRI (fMRI): Identification of presence and type of hyposmia", J COMPUT AS, 23(5), 1999, pp. 767-775

Abstract

Purpose: Our goal was to develop a rapid, simple, near-real-time method offunctional MRI (fMRI) to measure brain activation in response to olfactorystimuli, to use it to identify patients with smell loss (hyposmia), and todifferentiate their types of hyposmia. Method: fMRI was obtained in 16 patients with Type I hyposmia (who could detect but not recognize odors), 5 patients with Type II hyposmia (who couldboth detect and recognize odors, albeit with less than normal acuity), and2 volunteers with normal olfactory acuity by use of a rapid echo planar imaging technique in which one coronal brain section from the anterior cortical region was studied and a single olfactory stimulus was used. Actual scanning time performed by a variation of methods previously published required26 s. Three patients with Type I hyposmia were treated with theophylline 250-500 mg for 4-6 months and were studied before and after treatment. Results: Brain activation in response to olfactory stimuli was demonstrated using a new, rapid, and simple fMRI technique. Patients with Type I hyposmia had less activation than patients with Type II hyposmia. Both patient groups had less activation than normal volunteers. Activation in patients with Type I hyposmia was essentially absent from regions of the middle, frontal, orbitofrontal, and temporal cortex and was totally absent in regions ofinferior frontal, insular, and cingulate cortex. Activation in patients with Type II hyposmia was greatest in the middle frontal cortex and the orbitofrontal cortex bilaterally and was present in regions of inferior frontal,temporal, and cingulate cortex. Each patient with Type I hyposmia treated with theophylline had improved smell function to Type II hyposmia and aftertreatment demonstrated activation in inferior frontal and cingulate cortexbilaterally, whereas before treatment, no activation in these regions was apparent. Conclusion: We describe a simple, rapid technique that can be used in a practical clinical setting to identify patients with hyposmia and to differentiate patients with different types of olfactory loss. These studies confirm the presence and classification of patients with Type I and Type II hyposmia. Results of this study suggest that regions of the frontal cortex may act to guide or direct olfactory signals to other brain areas such as temporal and cingulate regions. Although these latter regions are involved with olfactory recognition, their role in olfactory memory, olfactory meaning, and attention needs to be considered.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 03:02:51