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Titolo:
Human cytochromes and some newer antidepressants: Kinetics, metabolism, and drug interactions
Autore:
Greenblatt, DJ; Von Moltke, LL; Harmatz, JS; Shader, RI;
Indirizzi:
Tufts Univ, Dept Pharmacol & Expt Therapeut, Sch Med, Boston, MA 02111 USATufts Univ Boston MA USA 02111 t Therapeut, Sch Med, Boston, MA 02111 USA Tufts Univ, Div Clin Pharmacol, Sch Med, Boston, MA 02111 USA Tufts Univ Boston MA USA 02111 n Pharmacol, Sch Med, Boston, MA 02111 USA New England Med Ctr, Boston, MA 02111 USA New England Med Ctr Boston MA USA 02111 and Med Ctr, Boston, MA 02111 USA
Titolo Testata:
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
fascicolo: 5, volume: 19, anno: 1999, supplemento:, 1
pagine: 23S - 35S
SICI:
0271-0749(199910)19:5<23S:HCASNA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEROTONIN REUPTAKE INHIBITORS; HUMAN LIVER-MICROSOMES; SPARTEINE OXIDATION POLYMORPHISM; HYDROXYLATION IN-VITRO; CLINICAL PHARMACOKINETICS; N-DEMETHYLATION; FLUVOXAMINE PHARMACOKINETICS; PHARMACODYNAMIC EVALUATION; DESIPRAMINE METABOLISM; SSRI ANTIDEPRESSANTS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
181
Recensione:
Indirizzi per estratti:
Indirizzo: Greenblatt, DJ Tufts Univ, Dept Pharmacol & Expt Therapeut, Sch Med, 136 Harrison Ave, Boston, MA 02111 USA Tufts Univ 136 Harrison Ave Boston MA USA02111 A 02111 USA
Citazione:
D.J. Greenblatt et al., "Human cytochromes and some newer antidepressants: Kinetics, metabolism, and drug interactions", J CL PSYCH, 19(5), 1999, pp. 23S-35S

Abstract

The appearance of selective serotonin reuptake inhibitor antidepressants in the mid-1980s caused the discipline of clinical psychopharmacology to refocus attention to the topics of drug metabolism and drug interactions. Thisarticle reviews the metabolic profiles of some newer antidepressants, the clinical implications of metabolic properties, and research methodology that can be applied in determining which specific human cytochromes P450 (CYP)mediate metabolic pathways. Also reviewed are the relative activities of various new antidepressants as inhibitors of CYPs, and the benefits and drawbacks of in vivo and in vitro methodologies for identification and quantitation of drug interactions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 15:34:27