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Titolo:
Chromatographic methods for analysis of aminoglycoside antibiotics
Autore:
Isoherranen, N; Soback, S;
Indirizzi:
Univ Helsinki, Dept Chem, Analyt Chem Lab, FIN-00014 Helsinki, Finland Univ Helsinki Helsinki Finland FIN-00014 ab, FIN-00014 Helsinki, Finland Kimron Vet Inst, Natl Residue Control Lab, Beit Dagan, Israel Kimron Vet Inst Beit Dagan Israel sidue Control Lab, Beit Dagan, Israel
Titolo Testata:
JOURNAL OF AOAC INTERNATIONAL
fascicolo: 5, volume: 82, anno: 1999,
pagine: 1017 - 1045
SICI:
1060-3271(199909/10)82:5<1017:CMFAOA>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFORMANCE LIQUID-CHROMATOGRAPHY; PRE-COLUMN DERIVATIZATION; PULSED AMPEROMETRIC DETECTION; MASS-SPECTROMETRY; ULTRAVIOLET DETECTION; MICRO-DETERMINATION; GENTAMICIN SULFATE; BIOLOGICAL-FLUIDS; NEOMYCIN SULFATE; SPECTROPHOTOMETRIC DETECTION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
102
Recensione:
Indirizzi per estratti:
Indirizzo: Soback, S Univ Helsinki, Dept Chem, Analyt Chem Lab, POB 55, FIN-00014 Helsinki, Finland Univ Helsinki POB 55 Helsinki Finland FIN-00014 lsinki, Finland
Citazione:
N. Isoherranen e S. Soback, "Chromatographic methods for analysis of aminoglycoside antibiotics", J AOAC INT, 82(5), 1999, pp. 1017-1045

Abstract

Aminoglycosides are antimicrobial agents used frequently in treatment of human and animal diseases caused by aerobic, gram-negative bacteria. Becauseof the toxicity of these compounds, considerable effort has been attributed to analysis of aminoglycoside content in drug preparations, in serum and urine specimen in therapeutic drug monitoring, and in edible animal tissuesin residue control. The present review emphasizes the analytical problems associated with aminoglycoside analysis. Screening methods based on microbiological and immunological procedures were briefly discussed. Gas chromatography and especially high-performance liquid chromatography appeared the most widely used chemical methods far the analysis of these compounds. Due tolack of volatility, chromophore, and hydrophility of aminoglycosides, mostmethods applied derivatization for enhancement of their chromatographic characteristics. The applicability and advantages of the various derivatization procedures were discussed in detail. A wide variety of detection methods, including mass spectrometry have been used. Packed column separation was generally used for gas chromatographic separation. In liquid chromatography, reversed phase, ion pair, ion exchange, and normal phase separation has been employed. Mass spectrometry, as a detection method, was discussed in detail. Extraction procedures from body fluids and tissues were emphasized. The performance and the operational conditions of the methods were describedand detailed information of the data was provided also in table format.

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Documento generato il 25/01/20 alle ore 16:30:18