Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Use of whole body hyperthermia as a method to heat inaccessible tumours uniformly: a phase III trial in canine brain masses
Autore:
Thrall, DE; Larue, SM; Powers, BE; Page, RL; Johnson, J; George, SL; Kornegay, JN; McEntee, MC; Levesque, DC; Smith, M; Case, BC; Dewhirst, MW; Gillette, EL;
Indirizzi:
N Carolina State Univ, Coll Vet Med, Raleigh, NC 27606 USA N Carolina State Univ Raleigh NC USA 27606 Vet Med, Raleigh, NC 27606 USA Colorado State Univ, Coll Vet Med & Biomed Sci, Ft Collins, CO 80523 USA Colorado State Univ Ft Collins CO USA 80523 Sci, Ft Collins, CO 80523 USA Duke Univ, Med Ctr, Durham, NC 27710 USA Duke Univ Durham NC USA 27710Duke Univ, Med Ctr, Durham, NC 27710 USA
Titolo Testata:
INTERNATIONAL JOURNAL OF HYPERTHERMIA
fascicolo: 5, volume: 15, anno: 1999,
pagine: 383 - 398
SICI:
0265-6736(199909/10)15:5<383:UOWBHA>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
SOFT-TISSUE SARCOMAS; RADIATION-THERAPY; RANDOMIZED TRIAL; LOCAL HYPERTHERMIA; BEARING DOGS; TUMORS; TEMPERATURE; CANCER; OXYGENATION; RECURRENT;
Keywords:
dog; hyperthermia; whole body hyperthermia; thermal dose; brain necrosis; brain tumour; radiation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Thrall, DE N Carolina State Univ, Coll Vet Med, 4700 Hillsborough St, Raleigh, NC 27606 USA N Carolina State Univ 4700 Hillsborough St Raleigh NC USA27606
Citazione:
D.E. Thrall et al., "Use of whole body hyperthermia as a method to heat inaccessible tumours uniformly: a phase III trial in canine brain masses", INT J HYPER, 15(5), 1999, pp. 383-398

Abstract

In this study, whole body hyperthermia (WBH) was assessed as a means of heating intracranial tumours uniformly. Twenty-five dogs received radiation therapy and 20 the combination of radiation and WBH. Total radiation dose was randomly assigned and was either 44, 48, 52, 56 or 60 Gy. Because of WBH toxicity, intercurrent disease or tumour progression, seven of the 45 dogs received less than the prescribed radiation dose. For WBH, the target rectal temperature was 42 degrees C for 2 h and three treatments were planned. In five of the 20 dogs randomized to receive WBH, only one WBH treatment wasgiven because of toxicity. WBH toxicity was severe in six dogs, and resulted in death or interruption in treatment. Most tumours did not undergo a complete response, making it impossible to differentiate tumour recurrence from brain necrosis as a cause of progressive neuropathy. Therefore, survivalwas the major study endpoint. There was no survival difference between groups. One-year survival probability (95% CI) for dogs receiving radiation therapy alone was 0.44 (0.25, 0.63) versus 0.40 (0.19, 0.63) for dogs receiving radiation and WBH. There was no difference in the incidence of brain necrosis in the two treatment groups. Results suggest that use of WBH alone toincrease the temperature of intracranial tumours as a means to improve radiation therapy outcome is not a successful strategy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 11:07:45