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Titolo:
Mycobacterium avium infection of epithelial cells results in inhibition ordelay in the release of interleukin-8 and RANTES
Autore:
Sangari, FJ; Petrofsky, M; Bermudez, LE;
Indirizzi:
Calif Pacific Med Ctr, Res Inst, Kuzell Inst Arthrit & Infect Dis, San Francisco, CA 94115 USA Calif Pacific Med Ctr San Francisco CA USA 94115 Francisco, CA 94115 USA
Titolo Testata:
INFECTION AND IMMUNITY
fascicolo: 10, volume: 67, anno: 1999,
pagine: 5069 - 5075
SICI:
0019-9567(199910)67:10<5069:MAIOEC>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACQUIRED-IMMUNODEFICIENCY-SYNDROME; HELICOBACTER-PYLORI; PROINFLAMMATORY CYTOKINES; COMPLEX INFECTION; STIMULATION; SECRETION; INVASION; TUBERCULOSIS; PATHOGENESIS; SALMONELLA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Bermudez, LE Calif Pacific Med Ctr, Res Inst, Kuzell Inst Arthrit & InfectDis, 2200 Webster St,Ste 305, San Francisco, CA 94115 USA Calif Pacific Med Ctr 2200 Webster St,Ste 305 San Francisco CA USA 94115
Citazione:
F.J. Sangari et al., "Mycobacterium avium infection of epithelial cells results in inhibition ordelay in the release of interleukin-8 and RANTES", INFEC IMMUN, 67(10), 1999, pp. 5069-5075

Abstract

Mycobacterium avium is an opportunistic pathogen in AIDS patients, who acquire the infection mainly through the gastrointestinal tract. Previous studies in vitro have shown that M, avium invades epithelial cells of both intestinal and laryngeal origin. In addition, M, avium enters the intestinal mucosa of healthy mice. Because M. avium invasion of the intestinal mucosa invivo initially is not accompanied by significant influx of inflammatory cells, we sought to determine whether M. avium would trigger chemokine release upon entry into epithelial cells by using HT-29 intestinal and HEp-2 laryngeal epithelial cell lines, Chemokine synthesis was measured both by the presence of specific mRNA and protein secretion in the cell culture supernatant as determined by enzyme-linked immunosorbent assay. Infection of HT-29 intestinal cells with M. avium did not induce the release of interleukin-8 (IL-8) or RANTES for up to 7 days postinfection. However, infection of HEp-2 cells resulted in the release of IL-8 and RANTES at 72 h, Similar findings were observed,vith other AIDS M. avium isolates belonging to different serovars, Secretion of IL-8 by HEp-2 cells was dependent upon bacterial uptake. In addition, prior infection with M. avium suppressed IL-8 production byHT-29 cells infected with Salmonella typhimurium, Our results suggest thatM. avium infection of epithelial cells is associated with a delay in IL-8 and RANTES production which, in the case of HT-29, is prolonged up to 1 week, These findings may explain the weak inflammatory response after intestinal mucosa invasion in mice and are probably related with the ability of thebacterium to evade the host's immune response.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 07:29:03