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Titolo:
How can Trichinella escape the host immune response
Autore:
Bruschi, F;
Indirizzi:
Univ Pisa, Dipartimento Patol Sperimentale Biotecnol Med Inf, Sez Patol Gen, I-56100 Pisa, Italy Univ Pisa Pisa Italy I-56100 Med Inf, Sez Patol Gen, I-56100 Pisa, Italy
Titolo Testata:
HELMINTHOLOGIA
fascicolo: 3, volume: 36, anno: 1999,
pagine: 179 - 184
SICI:
0440-6605(199909)36:3<179:HCTETH>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEWBORN LARVAE; MONOCLONAL-ANTIBODY; SPIRALIS INFECTION; HUMAN-NEUTROPHILS; PARASITE; MICE; ADHESION; RATS; GLYCOPROTEIN; ANTIGENS;
Keywords:
Trichinella; evasion mechanisms; immunomodulation; hypereosinophilia; polyclonal lymphocyte activation; host leukocyte function modification;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Bruschi, F Univ Pisa, Dipartimento Patol Sperimentale Biotecnol Med Inf, Sez Patol Gen, Via Roma 55, I-56100 Pisa, Italy Univ Pisa Via Roma 55 Pisa Italy I-56100 , I-56100 Pisa, Italy
Citazione:
F. Bruschi, "How can Trichinella escape the host immune response", HELMINTHOL, 36(3), 1999, pp. 179-184

Abstract

This review deals with the mechanisms used by the nematode of the genus Trichinella to prevent or "down regulate" host immune response. All these mechanisms are discussed in details. There are antigen-dependent mechanisms some of which are anatomic seclusion, stage-specificity, molecular mimicry and antigen shedding and renewal. The parasite can affect also directly the host immune response by immunomodulation. This can be exerted at central level through immune suppression, polyclonal lymphocyte activation and hypereosinophilia induction as well as at peripheral level by modi- fying the hostleukocyte functions, inducing the production of blocking antibodies or of immune complexes, inhibiting the complement MAC assembly.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 03:25:31