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Titolo:
Is endoscopic paravascular injection of sclerosing agents reasonable in the control of GI bleeding?
Autore:
Tatemichi, M; Nagata, H; Sekizuka, E; Morishita, T; Mizuki, A; Ishii, H;
Indirizzi:
Keio Univ, Sch Med, Dept Internal Med, Shinjuku Ku, Tokyo 160, Japan Keio Univ Tokyo Japan 160 pt Internal Med, Shinjuku Ku, Tokyo 160, Japan Saiseikai Cent Hosp, Dept Internal Med, Tokyo, Japan Saiseikai Cent Hosp Tokyo Japan t Hosp, Dept Internal Med, Tokyo, Japan Natl Saitama Hosp, Inst Clin Res, Tokyo, Japan Natl Saitama Hosp Tokyo Japan Saitama Hosp, Inst Clin Res, Tokyo, Japan Shizuoka Red Cross Hosp, Dept Internal Med, Tokyo, Japan Shizuoka Red Cross Hosp Tokyo Japan sp, Dept Internal Med, Tokyo, Japan
Titolo Testata:
GASTROINTESTINAL ENDOSCOPY
fascicolo: 4, volume: 50, anno: 1999,
pagine: 499 - 505
SICI:
0016-5107(199910)50:4<499:IEPIOS>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
UPPER GASTROINTESTINAL HEMORRHAGE; PEPTIC-ULCER; EPINEPHRINE INJECTION; ESOPHAGEAL-VARICES; THERAPY; SCLEROTHERAPY; ADRENALINE; HEMOSTASIS; ALCOHOL; TRIAL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Nagata, H Keio Univ, Sch Med, Dept Internal Med, Shinjuku Ku, 35 Shinanomachi, Tokyo160, Japan Keio Univ 35 Shinanomachi Tokyo Japan 160 achi, Tokyo160, Japan
Citazione:
M. Tatemichi et al., "Is endoscopic paravascular injection of sclerosing agents reasonable in the control of GI bleeding?", GASTROIN EN, 50(4), 1999, pp. 499-505

Abstract

Background: The pharmacologic response and microvascular effects associated with the endoscopic injection of sclerosing agents around vessels (paravascular injection) to stop bleeding from the digestive tract remain to be clarified. Methods: Using in vivo microscopy, we directly visualized submucosal microvessels of the rat stomach and intestine. We studied differences among sclerosing agents in thrombus formation and vascular diameter change that occurthrough a pharmacologic response and/or local compression after topical application or paravascular injection of the agents. Results: Except for absolute ethanol, topical application of the agents did not cause constriction or thrombi in either arterioles or venules. Polidocanol topical application and paravascular injection significantly dilated arterioles. Injecting ethanolamine oleate near venules constricted them thelongest and most effectively, but vasoconstriction in arterioles was transient. Injecting absolute ethanol formed long-lasting thrombi and caused vasoconstriction in venules, but arteriole thrombi persisted no more than 3 minutes. The vascular response to thrombin did not significantly differ from that to physiologic saline. Conclusion: The paravascular injection of ethanolamine oleate, because of its long-lasting vasoconstriction, or of absolute ethanol, because of its thrombogenic effect, is a valid therapeutic approach to treating venous bleeding. The efficacy of paravascular injection of sclerosing agents for treating acute arterial bleeding, however, is not supported in this experimentalmodel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 12:09:59