Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Clinical significance of MCP-1 levels in BALF and serum in patients with interstitial lung diseases
Autore:
Suga, M; Iyonaga, K; Ichiyasu, H; Saita, N; Yamasaki, H; Ando, M;
Indirizzi:
Kumamoto Univ, Sch Med, Dept Internal Med 1, Kumamoto 8600811, Japan Kumamoto Univ Kumamoto Japan 8600811 rnal Med 1, Kumamoto 8600811, Japan
Titolo Testata:
EUROPEAN RESPIRATORY JOURNAL
fascicolo: 2, volume: 14, anno: 1999,
pagine: 376 - 382
SICI:
0903-1936(199908)14:2<376:CSOMLI>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
MONOCYTE CHEMOATTRACTANT PROTEIN-1; IDIOPATHIC PULMONARY FIBROSIS; BRONCHOALVEOLAR LAVAGE FLUID; BLOOD MONONUCLEAR LEUKOCYTES; KL-6; PNEUMONITIS; SARCOIDOSIS; EXPRESSION; CHEMOTAXIS; ANTIGEN;
Keywords:
idiopathic pulmonary fibrosis; interstitial lung disease; monocyte chemoattractant protein-1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Suga, M Kumamoto Univ, Sch Med, Dept Internal Med 1, 1-1-1 Honjo, Kumamoto8600811, Japan Kumamoto Univ 1-1-1 Honjo Kumamoto Japan 8600811 o 8600811, Japan
Citazione:
M. Suga et al., "Clinical significance of MCP-1 levels in BALF and serum in patients with interstitial lung diseases", EUR RESP J, 14(2), 1999, pp. 376-382

Abstract

It has previously been reported that the expression of monocyte chemoattractant protein-1 (MCP-1) in the lung tissues of patients with idiopathic pulmonary fibrosis (IPF) was different from that in the tissues of patients with other interstitial lung diseases (ILDs). The aim of this study was to determine whether this difference reflects the amount of MCP-1 in the bronchoalveolar lavage fluid (BALF) or serum of patients with ILD, and whether such a correlation, if it exists, is clinically useful. MCP-1 concentrations in the BALF and sera were evaluated in 86 patients with ILDs including IPF, acute interstitial pneumonia, interstitial pneumoniawith collagen vascular disease (IP-CVD), chronic interstitial pneumonia (CLP), bronchiolitis obliterans-organizing pneumonia, sarcoidosis, hypersensitivity pneumonitis, and in 10 normal healthy volunteers who were controls (NC). BALF MCP-1 levels were significantly elevated in the IPF, LP-CVD, CIP and sarcoidosis groups compared with the NC group. The level in the IPF group was significantly higher than that in any other patient group. Serum MCP-1 levels in the IPF, IP-CVD, CIP and sarcoidosis groups were significantly higher than the NC group. No statistical difference was found in serum MCP-1 levels between the IPF, IP-CVD and CLP groups. BALF MCP-1 levels were significantly higher than serum MCP-1 levels in the IPF group and lower than in the IP-CVD and CIP groups. Serum MCP-1 levels correlated with the clinical course of ILD treated with corticosteroid therapy. These results shaw that measurement of monocyte chemoattractant protein-1 levels in both bronchoalveolar lavage fluid and serum may be helpful in discriminating idiopathic pulmonary fibrosis from other types of interstitial lung disease and that monitoring of serum monocyte chemoattractant protein-1 may be useful for predicting the clinical course of interstitial lung diseases.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 22:26:10