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Titolo:
Glucose transport in brain and retina: Implications in the management and complications of diabetes
Autore:
Kumagai, AK;
Indirizzi:
Univ Michigan, Sch Med, Dept Internal Med, Michigan Diabet Res & Training Ctr, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 raining Ctr, Ann Arbor, MI 48109 USA
Titolo Testata:
DIABETES-METABOLISM RESEARCH AND REVIEWS
fascicolo: 4, volume: 15, anno: 1999,
pagine: 261 - 273
SICI:
1520-7552(199907/08)15:4<261:GTIBAR>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL GROWTH-FACTOR; COUNTERREGULATORY HORMONAL RESPONSES; ELECTRON-MICROSCOPIC IMMUNOGOLD; INTENSIVE INSULIN THERAPY; PIGMENT EPITHELIAL-CELLS; BLOOD-TISSUE BARRIERS; GLUT1 MESSENGER-RNA; RAT MESANGIAL CELLS; GENE-EXPRESSION; CHRONIC HYPERGLYCEMIA;
Keywords:
blood-brain barrier; blood-retinal barrier; glucose transport; hypoglycemia; diabetic retinopathy; diabetes;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
162
Recensione:
Indirizzi per estratti:
Indirizzo: Kumagai, AK Univ Michigan, Sch Med, Dept Internal Med, Michigan Diabet Res& Training Ctr, 5570 MSRB-2, Ann Arbor, MI 48109 USA Univ Michigan 5570 MSRB-2 Ann Arbor MI USA 48109 MI 48109 USA
Citazione:
A.K. Kumagai, "Glucose transport in brain and retina: Implications in the management and complications of diabetes", DIABET M R, 15(4), 1999, pp. 261-273

Abstract

Neural tissue is entirely dependent on glucose for normal metabolic activity. Since glucose stores in the brain and retina are negligible compared toglucose demand, metabolism in these tissues is dependent upon adequate glucose delivery from the systemic circulation. In the brain, the critical interface for glucose transport is at the brain capillary endothelial cells which comprise the blood-brain barrier (BBB). In the retina, transport occursacross the retinal capillary endothelial cells of the inner blood-retinal barrier (BRB) and the retinal pigment epithelium of the outer BRB. Because glucose transport across these barriers is mediated exclusively by the sodium-independent glucose transporter GLUT1, changes in endothelial glucose transport and GLUT1 abundance in the barriers of the brain and retina may have profound consequences on glucose delivery to these tissues and major implications in the development of two major diabetic complications, namely insulin-induced hypoglycemia and diabetic retinopathy. This review discusses the regulation of brain and retinal glucose transport and glucose transporter expression and considers the role of changes in glucose transporter expression in the development of two of the most devastating complications of longstanding diabetes mellitus and its management. Copyright (C) 1999 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 08:43:37