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Titolo:
Evidence for a functional role of the cholecystokinin-B/gastrin receptor in the human fetal and adult pancreas
Autore:
Saillan-Barreau, C; Dufresne, M; Clerc, P; Sanchez, D; Corominola, H; Moriscot, C; Guy-Crotte, O; Escrieut, C; Vaysse, N; Gomis, R; Tarasova, N; Fourmy, D;
Indirizzi:
CHU Rangueil, INSERM, U151, Inst Louis Bugnard, F-31403 Toulouse 4, FranceCHU Rangueil Toulouse France 4 Louis Bugnard, F-31403 Toulouse 4, France Fac Med, Grp Rech Glandes Exocrines, Marseille, France Fac Med MarseilleFrance Grp Rech Glandes Exocrines, Marseille, France Hosp Clin, Sch Med, Endocrinol & Diabet Unit, Barcelona, Spain Hosp Clin Barcelona Spain d, Endocrinol & Diabet Unit, Barcelona, Spain NCI, ABL Basic Res Program, Frederick Canc Res & Dev Ctr, Frederick, MD 21701 USA NCI Frederick MD USA 21701 ck Canc Res & Dev Ctr, Frederick, MD 21701 USA
Titolo Testata:
DIABETES
fascicolo: 10, volume: 48, anno: 1999,
pagine: 2015 - 2021
SICI:
0012-1797(199910)48:10<2015:EFAFRO>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR-ALPHA; INSULIN-SECRETION; HUMAN BRAIN; DIFFERENTIAL EXPRESSION; PHYSIOLOGICAL-ROLE; HORMONE-SECRETION; GASTRIN; GLUCAGON; CCK; LOCALIZATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Fourmy, D CHU Rangueil, INSERM, U151, Inst Louis Bugnard, Bat L3, F-31403 Toulouse 4, France CHU Rangueil Bat L3 Toulouse France 4 -31403 Toulouse 4, France
Citazione:
C. Saillan-Barreau et al., "Evidence for a functional role of the cholecystokinin-B/gastrin receptor in the human fetal and adult pancreas", DIABETES, 48(10), 1999, pp. 2015-2021

Abstract

Gastrin (G) and cholecystokinin (CCK) are gastrointestinal neuropeptides that are released into circulation during a meal. G is also transiently expressed during embryogenic and early ontogenic development of the pancreas and is believed to act on islet-cell. development. Both peptides act on pancreatic endocrine function; however, the effects are dependent on the speciesand on cellular and molecular underlying mechanisms that remain poorly characterized. Since CCK-B/G subtype receptor is predominant over the CCK-A subtype in the human pancreas, me hypothesized that it could be expressed by islet cells. Here we present reverse transcription-polymerase chain reaction and immunohistochemistry data demonstrating that the CCK-B/G receptor is expressed in islet cells and that islet glucagon-producing cells are the major site of CCK-B/G receptor expression in adult and fetal pancreas, Moreover, G immunoreactivity was detected in the fetal human pancreas at embryogenic week 22, G- and CCK-stimulated glucagon are released from purified human islets, Concentration of CCK and G eliciting a half-maximal level of glucagon secretion were 13 +/- 6 and 8 +/- 5 pmol/l, respectively, Maximal glucagon secretion was achieved in the presence of 30 pmol/l peptides and was similar to that obtained in the presence of 10 mmol/l L-arginine (1.6 pmol.ml(-1).90 min(-1)). The nonpeptide antagonist of the CCK-B/G receptor, RPR-101048, fully inhibited CCK- and G-stimulated glucagon secretion at 100 nmol/l concentration. These data are consistent with the view that the CCK-B/G receptor is involved in glucose homeostasis in adult humans and mediates the autocrine effects of G on islet differentiation and growth in the fetal pancreas.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 16:22:19