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Titolo:
No effect of insulin on glucose blood-brain barrier transport and cerebralmetabolism in humans
Autore:
Hasselbalch, SG; Knudsen, GM; Videbaek, C; Pinborg, LH; Schmidt, JF; Holm, S; Paulson, OB;
Indirizzi:
Univ Copenhagen Hosp, Rigshosp, Dept Neurol, Neurobiol Res Unit N9201, DK-2100 Copenhagen, Denmark Univ Copenhagen Hosp Copenhagen Denmark DK-2100 2100 Copenhagen, Denmark Univ Copenhagen Hosp, Rigshosp, Neurobiol Res Unit, DK-2100 Copenhagen, Denmark Univ Copenhagen Hosp Copenhagen Denmark DK-2100 2100 Copenhagen, Denmark Univ Copenhagen Hosp, Rigshosp, Dept Nucl Med, DK-2100 Copenhagen, DenmarkUniv Copenhagen Hosp Copenhagen Denmark DK-2100 2100 Copenhagen, Denmark Univ Copenhagen Hosp, Rigshosp, Dept Neuroanesthesiol, DK-2100 Copenhagen,Denmark Univ Copenhagen Hosp Copenhagen Denmark DK-2100 -2100 Copenhagen,Denmark
Titolo Testata:
DIABETES
fascicolo: 10, volume: 48, anno: 1999,
pagine: 1915 - 1921
SICI:
0012-1797(199910)48:10<1915:NEOIOG>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; LUMPED CONSTANT; F-18 FLUORODEOXYGLUCOSE; RAT-BRAIN; HETEROGENEITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Hasselbalch, SG Univ Copenhagen Hosp, Rigshosp, Dept Neurol, Neurobiol ResUnit N9201, Blegdamsvej 9, DK-2100 Copenhagen, Denmark Univ Copenhagen Hosp Blegdamsvej 9 Copenhagen Denmark DK-2100
Citazione:
S.G. Hasselbalch et al., "No effect of insulin on glucose blood-brain barrier transport and cerebralmetabolism in humans", DIABETES, 48(10), 1999, pp. 1915-1921

Abstract

The effect of hyperinsulinemia on glucose blood-brain barrier (BBB) transport and cerebral metabolism (CMRglc) was studied using the intravenous double-indicator method and positron emission tomography using [F-18]fluorodeoxyglucose as tracer (PET-FDG). Sixteen normal healthy control subjects (25 +/- 4 years old) mere studied twice during a euglycemic and a euglycemic-hyperinsulinemic condition. Our hypothesis was that high physiologic levels ofinsulin did not affect the BBB transport or net metabolism of glucose. During insulin infusion, arterial plasma insulin levels increased from 48.5 to499.4 pmol/l. The permeability-surface area products for glucose and FDG BBB transport obtained with the double-indicator method remained constant during hyperinsulinemia. Similarly using PET-FDG, no changes mere observed inthe unidirectional clearance of FDG from blood to brain. k(2)* (FDG transport from brain to blood) increased significantly by 15 and 18% (gray and white matter, respectively), and k(4)* (dephosphorylation of FDG) increased by 18%. The increase in k(2)* may be caused by insulin inducing a decrease in the available FDG brain pool, The increase in k(2)* may be related to an increased loss of labeled products during insulin fusion. Irrespective of these changes, CMRglc remained unchanged in all brain regions. We conclude that hyperinsulinemia within the normal physiologic range does not affect BBB glucose transport or net cerebral glucose metabolism.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 19:35:44