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Titolo:
Lineage-tracing cells born in different domains along the PD axis of the developing Drosophila leg
Autore:
Weigmann, K; Cohen, SM;
Indirizzi:
European Mol Biol Lab, D-69117 Heidelberg, Germany European Mol Biol Lab Heidelberg Germany D-69117 117 Heidelberg, Germany
Titolo Testata:
DEVELOPMENT
fascicolo: 17, volume: 126, anno: 1999,
pagine: 3823 - 3830
SICI:
0950-1991(199909)126:17<3823:LCBIDD>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-RANGE ACTION; PROXIMAL-DISTAL AXIS; MORPHOGEN GRADIENT; DISTINCT MECHANISMS; PATTERN-FORMATION; WINGLESS PROTEIN; GENE-EXPRESSION; HEDGEHOG; ENCODES; DPP;
Keywords:
lineage-tracing; Drosophila; leg; Wingless; Hedgehog; Dpp;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Cohen, SM European Mol Biol Lab, Meyerhofstr 1, D-69117 Heidelberg, Germany European Mol Biol Lab Meyerhofstr 1 Heidelberg Germany D-69117
Citazione:
K. Weigmann e S.M. Cohen, "Lineage-tracing cells born in different domains along the PD axis of the developing Drosophila leg", DEVELOPMENT, 126(17), 1999, pp. 3823-3830

Abstract

Patterning of the developing limbs by the secreted signaling proteins Wingless, Hedgehog and Dpp takes place while the imaginal discs are growing rapidly. Cells born in regions of high ligand concentration may be displaced through growth to regions of lower ligand concentration. We have used a novel lineage-tagging method to address the reversibility of cell fate specification by morphogen gradients. We find that responses to Hedgehog and Dpp inthe wing disc are readily reversible, In the leg, we find that cells readily adopt more distal fates, but do not normally shift from distal to proximal fate, However, they can do so if given a growth advantage. These resultsindicate that cell fate specification by morphogen gradients remains largely reversible while the imaginal discs grow In other systems, where growth and patterning are uncoupled, nonreversible specification events or 'ratchet' effects may be of functional significance.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 21:53:19