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Titolo:
CHEMICAL, ENZYMATIC AND STRUCTURAL STUDIES IN MOLECULAR GLYCOBIOLOGY
Autore:
MCGARVEY GJ; WONG CH;
Indirizzi:
SCRIPPS CLIN & RES INST,DEPT CHEM,10550 N TORREY PINES RD LA JOLLA CA92037 SCRIPPS CLIN & RES INST,SKAGGS INST CHEM BIOL LA JOLLA CA 92037
Titolo Testata:
Liebigs Annalen
fascicolo: 6, , anno: 1997,
pagine: 1059 - 1074
SICI:
0947-3440(1997):6<1059:CEASSI>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
SIALYL-LEWIS-X; ONE-POT SYNTHESIS; LEUKOCYTE ADHESION MOLECULE-1; BLOOD-GROUP ANTIGENS; E-SELECTIN; ORGANIC-SYNTHESIS; CELL-ADHESION; CARBOHYDRATE LIGAND; CATALYZED SYNTHESIS; P-SELECTIN;
Keywords:
MOLECULAR GLYCOBIOLOGY; OLIGOSACCHARIDES; CARBOHYDRATES; MOLECULAR RECOGNITION; POLYVALENT RECEPTOR-LIGAND INTERACTION; ENZYME INHIBITORS; CARBOHYDRATE MIMETICS; MULTIENZYME SYNTHESIS; CARBOHYDRATE SYNTHESIS; RECOMBINANT ENZYMES; GLYCOSYLTRANSFERASES; GLYCOSIDASES;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
186
Recensione:
Indirizzi per estratti:
Citazione:
G.J. Mcgarvey e C.H. Wong, "CHEMICAL, ENZYMATIC AND STRUCTURAL STUDIES IN MOLECULAR GLYCOBIOLOGY", Liebigs Annalen, (6), 1997, pp. 1059-1074

Abstract

Carbohydrates are increasingly appreciated for their critical roles in biological functions. Driving these studies addressing the molecularbasis of carbohydrate-mediated events is the availability of natural and unnatural carbohydrates. Recently, new methods of enzymatic synthesis have been developed that now afford rapid access to complex, structurally diverse oligosaccharides on large scales, This methodology hasbeen essential to gaining insight into the molecular details of important carbohydrate recognition phenomena that are associated with many signaling processes, This review summarizes recent chemical studies examining selectin/sialyl Lewis(x) binding, a key event in inflammation and metastasis, and describes the development of carbohydrate mimeticsthat may offer leads to new therapeutic agents. In addition, combinatorial synthesis has been used to prepare carbohydrate mimetics to neomycin B, an aminoglycoside that binds RNA involved in HIV infection, and chemoenzymatic methodology has been applied to the design and synthesis of mechanism-based inhibitors of glycoprocessing enzymes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 22:19:32