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Titolo:
No evidence for a role of human herpesvirus type 8 in sarcoidosis: molecular and serological analysis
Autore:
Lebbe, C; Agbalika, F; Flageul, B; Pellet, C; Rybojad, M; Cordoliani, F; Farge, D; Vignon-Pennamen, MD; Sheldon, J; Morel, P; Calvo, F; Schulz, TF;
Indirizzi:
Hop St Louis, Dept Dermatol, F-75010 Paris, France Hop St Louis Paris France F-75010 , Dept Dermatol, F-75010 Paris, France Hop St Louis, Pharmacol Lab, F-75010 Paris, France Hop St Louis Paris France F-75010 , Pharmacol Lab, F-75010 Paris, France Hop St Louis, Microbiol Lab, Virol Unit, F-75010 Paris, France Hop St Louis Paris France F-75010 Lab, Virol Unit, F-75010 Paris, France Hop St Louis, Dept Internal Med, F-75010 Paris, France Hop St Louis Paris France F-75010 pt Internal Med, F-75010 Paris, France Hop St Louis, Pathol Lab, F-75010 Paris, France Hop St Louis Paris France F-75010 uis, Pathol Lab, F-75010 Paris, France Univ Liverpool, Dept Med Microbiol, Liverpool L69 3BX, Merseyside, EnglandUniv Liverpool Liverpool Merseyside England L69 3BX , Merseyside, England
Titolo Testata:
BRITISH JOURNAL OF DERMATOLOGY
fascicolo: 3, volume: 141, anno: 1999,
pagine: 492 - 496
SICI:
0007-0963(199909)141:3<492:NEFARO>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
SARCOMA-ASSOCIATED HERPESVIRUS; KAPOSIS-SARCOMA; HUMAN-HERPESVIRUS-8; SEQUENCES; SEROPREVALENCE; TRANSMISSION; ANTIBODIES; INFECTION; ONCOGENE; PROTEINS;
Keywords:
Africa; DNA sequencing; epidemiology; France; French West Indies; human herpesvirus type 8; polymerase chain reaction; sarcoidosis; serology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Lebbe, C Hop St Louis, Dept Dermatol, 1 Ave Claude Vellefaux, F-75010 Paris, France Hop St Louis 1 Ave Claude Vellefaux Paris France F-75010 France
Citazione:
C. Lebbe et al., "No evidence for a role of human herpesvirus type 8 in sarcoidosis: molecular and serological analysis", BR J DERM, 141(3), 1999, pp. 492-496

Abstract

The aim of this study was to analyse the association between human herpesvirus type 8 (HHV8) and sarcoidosis, Using nested polymerase chain reaction (PCR), we tested the presence of HHV8 DNA sequences in 13 skin specimens and peripheral blood mononuclear cells from eight patients suffering from sarcoidosis. We also looked for the presence of HHV8 antibodies in the sera of28 patients with sarcoidosis using three techniques: two indirect immunofluorescence assays and an enzyme-linked immunosorbent assay with recombinantcapsid protein fragment encoded by open-reading frame 65. HHV8 PCR analysis was negative while HHV8 serological studies showed an overall prevalence of 18% among patients suffering from sarcoidosis: 43% in patients from sub-Saharan Africa, 17% in patients from Northern Africa, 12.5% in patients from the French West Indies and 0% in French patients. In conclusion, our results do not indicate an association between HHV8 and sarcoidosis but reflectthe seroepidemiology of this virus in different geographical regions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 16:32:38