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Titolo:
A comparison of the residual effects of zaleplon and zolpidem following administration 5 to 2 h before awakening
Autore:
Danjou, P; Paty, I; Fruncillo, R; Worthington, P; Unruh, M; Cevallos, W; Martin, P;
Indirizzi:
Wyeth Ayerst Res, Clin Pharmacol, F-92031 Paris, France Wyeth Ayerst Res Paris France F-92031 n Pharmacol, F-92031 Paris, France Wyeth Ayerst Res, Radnor, PA 19087 USA Wyeth Ayerst Res Radnor PA USA 19087 eth Ayerst Res, Radnor, PA 19087 USA Wyeth Ayerst Biostat, Slough, Berks, England Wyeth Ayerst Biostat Slough Berks England iostat, Slough, Berks, England
Titolo Testata:
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
fascicolo: 3, volume: 48, anno: 1999,
pagine: 367 - 374
SICI:
0306-5251(199909)48:3<367:ACOTRE>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLACEBO; DRUGS; PSYCHOMOTOR; VOLUNTEERS; CL-284,846; KINETICS; SINGLE;
Keywords:
hypnotic; residual effects; sedative; zaleplon; zolpidem;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Paty, I Wyeth Ayerst Res, Clin Pharmacol, Le Wilson 11,80 Ave Charles De Gaulle, F-92031 Paris, France Wyeth Ayerst Res Le Wilson 11,80 Ave Charles De Gaulle Paris France F-92031
Citazione:
P. Danjou et al., "A comparison of the residual effects of zaleplon and zolpidem following administration 5 to 2 h before awakening", BR J CL PH, 48(3), 1999, pp. 367-374

Abstract

Aims To compare the duration of the residual hypnotic and sedative effectsof zaleplon with those of zolpidem and placebo following nocturnal administration at various times before morning awakening. Methods Zaleplon 10 mg, zolpidem 10 mg, or placebo was administered double-blind to 36 healthy subjects under standardized conditions in a six-period, incomplete-block, crossover study. Subjects were gently awakened and given medication at predetermined times 5, 4, 3, or 2 h before morning awakening, which occurred 8 h after bedtime. When the subjects awoke in the morning, a battery of subjective and objective assessments of residual effects of hypnotics was administered. Results No residual effects were demonstrated after zaleplon 10 mg, when administered as little as 2 h before waking, on either subjective or objective assessments, whereas zolpidem 10 mg showed significant residual effects on DSST and memory (immediate and delayed free recall) after administrationup to 5 h before waking and choice reaction time, critical flicker fusion threshold and Sternberg memory scanning after administration up to 4 h before waking. Residual effects of zolpidem were apparent in all objective and subjective measurements when the drug was administered later in the night. Conclusions The present results demonstrate that zaleplon at the dose of 10 mg is free of residual hypnotic or sedative effects when administered nocturnally as little as 2 h before waking in normal subjects. In contrast, residual effects of zolpidem are still apparent on objective assessments up to 5 h after nocturnal administration, longer than has been reported from studies involving daytime administration.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 14:26:21