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Titolo:
Frontal, midbrain and striatal dopaminergic function in early and advancedParkinson's disease A 3D [F-18]dopa-PET study
Autore:
Rakshi, JS; Uema, T; Ito, K; Bailey, DL; Morrish, PK; Ashburner, J; Dagher, A; Jenkins, IH; Friston, KJ; Brooks, DJ;
Indirizzi:
Hammersmith Hosp, MRC, Cyclotron Unit, London W12 0NN, England HammersmithHosp London England W12 0NN on Unit, London W12 0NN, England Inst Neurol, Wellcome Dept Cognit Neurol, London W12 0NN, England Inst Neurol London England W12 0NN ognit Neurol, London W12 0NN, England Inst Neurol, Dept Clin Neurol, London W12 0NN, England Inst Neurol London England W12 0NN Clin Neurol, London W12 0NN, England Natl Inst Longev Sci, Dept Biofunct Res, Obu, Japan Natl Inst Longev Sci Obu Japan ongev Sci, Dept Biofunct Res, Obu, Japan
Titolo Testata:
BRAIN
, volume: 122, anno: 1999,
parte:, 9
pagine: 1637 - 1650
SICI:
0006-8950(199909)122:<1637:FMASDF>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; DOPA DECARBOXYLASE ACTIVITY; IDIOPATHIC PARKINSONS-DISEASE; STRIATAL DOPAMINERGIC SYSTEM; SUBSTANTIA-NIGRA; 6-HYDROXYDOPAMINE LESIONS; PREFRONTAL CORTEX; RAT STRIATUM; 3D PET; BRAIN;
Keywords:
Parkinson's disease; 3D [F-18]dopa; focal changes; extrastriatal; progression;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
67
Recensione:
Indirizzi per estratti:
Indirizzo: Rakshi, JS Hammersmith Hosp, MRC, Cyclotron Unit, Du Cane Rd, London W12 0NN, England Hammersmith Hosp Du Cane Rd London England W12 0NN NN, England
Citazione:
J.S. Rakshi et al., "Frontal, midbrain and striatal dopaminergic function in early and advancedParkinson's disease A 3D [F-18]dopa-PET study", BRAIN, 122, 1999, pp. 1637-1650

Abstract

We have studied focal changes in dopaminergic function throughout the brain volume in early and advanced Parkinson's disease by applying statistical parametric mapping (SPM) to 3D [F-18]dopa-PET. Data from seven early hemi-Parkinson's disease and seven advanced bilateral Parkinson's disease patients were compared with that from 12 normal controls. Parametric images of [F-18]dopa influx rate constant (K-i(o)) were generated for each subject from dynamic 3D [F-18]dopa datasets and transformed into standard stereotactic space. Significant changes in mean voxel [F-18]dopa K-i(o) values between the normal control group and each Parkinson's disease group were localized with SPM. Conventional region of interest analysis was also applied to comparable regions on the untransformed image datasets. In early left hemi-Parkinson's disease, significant extrastriatal increases in [F-18]dopa K-i(o) were observed in the left anterior cingulate gyrus and the dorsal midbrain region (P < 0.05, corrected) along with decreases in striatal [F-18]dopa K-i(o). In advanced Parkinson's disease, significant extrastriatal decreases in [F-18]dopa K-i(o) were observed in the ventral and dorsal midbrain regions (P < 0.05, corrected). No significant changes in [F-18]dopa K-i(o) were observed in the anterior cingulate region. In a direct comparison between the early and late Parkinson's disease groups, we observed relative [F-18]dopa K-i(o) reductions in ventral and dorsal midbrain, and dorsal pontine regions along with striatal [F-18]dopa K-i(o) reductions. Similiar results were found with a region of interest approach, on non-transformed data, except for the focal midbrain [F-18]dopa K-i(o) increase seen in early Parkinson's disease. In conclusion, using SPM with [F-18]dopa-PET, we have objectively localized changes in extrastriatal, pre-synaptic dopaminergic function in Parkinson's disease. The significance of the increased dopaminergic activity of anterior cingulate in early Parkinson's disease remains unclear, but maybe compensatory. The [F-18]dopa signal in dorsal midbrain and pontine regions suggests that [F-18]dopa is taken up by serotonergic and noradrenergic neurons which also degenerate in advanced Parkinson's disease. This suggests, therefore, that Parkinson's disease is a monoaminergic neurodegenerativedisorder.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 06:25:38