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Titolo:
Duration of untreated psychosis in first-episode schizophrenia: Marker or determinant of course?
Autore:
McGlashan, TH;
Indirizzi:
Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06520 USA Yale Univ New Haven CT USA 06520 , Dept Psychiat, New Haven, CT 06520 USA Yale Psychiat Inst, New Haven, CT USA Yale Psychiat Inst New Haven CT USA ale Psychiat Inst, New Haven, CT USA
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 7, volume: 46, anno: 1999,
pagine: 899 - 907
SICI:
0006-3223(19991001)46:7<899:DOUPIF>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
SERIOUS MENTAL-ILLNESS; LONG-TERM COURSE; 1ST-EPISODE SCHIZOPHRENIA; FOLLOW-UP; EDITORS INTRODUCTION; TREATMENT RESPONSE; VERMONT 3-DECADE; DISORDERS; ONSET; INTERVENTION;
Keywords:
first episode; schizophrenia; duration of untreated psychosis; early detection; deficit processes; early intervention; secondary prevention;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: McGlashan, TH Yale Univ, Sch Med, Dept Psychiat, POB 208038, New Haven, CT06520 USA Yale Univ POB 208038 New Haven CT USA 06520 en, CT 06520 USA
Citazione:
T.H. McGlashan, "Duration of untreated psychosis in first-episode schizophrenia: Marker or determinant of course?", BIOL PSYCHI, 46(7), 1999, pp. 899-907

Abstract

The natural history of schizophrenia is often chronic and debilitating an enduring fact that draws attention to the first episode and early course ofthe disorder when neurobiological deficits apparently form. Many recent studies have focused on the duration of untreated psychosis (DUP) in first-episode patients for reasons that are reviewed here. DUP is often months or years in length, making it a major public mental health problem. Reducing DUP through early detection may be possible from a service systems perspective. This may be very important because earlier treatment not only reduces acute psychotic symptoms, but may also improve long-term prognosis by attenuating the deficit processes active at this time; processes that are either signaled by or a product of DUP. Finally, DUP appears to influence sampling in first-episode research in that longer DUP is associated with higher recruitment refusal rates to studies. For all of these reasons, DUP should be added to the battery of descriptive variables routinely collected on all patients with schizophrenia, whether for treatment or research. Biol Psychiatry 1999;46:899-907 (C) 1999 Society of Biological psychiatry.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 22:18:12