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Titolo:
Prevention of postoperative nausea and vomiting in gynaecological laparotomies: A comparison of tropisetron and ondansetron
Autore:
Tsui, SL; Ng, KFJ; Wong, LC; Tang, GWK; Pun, TC; Yang, JCS;
Indirizzi:
Queen Mary Hosp, Dept Anaesthesiol, Div Pain Management, Pokfulam, Hong Kong Queen Mary Hosp Pokfulam Hong Kong Pain Management, Pokfulam, Hong Kong
Titolo Testata:
ANAESTHESIA AND INTENSIVE CARE
fascicolo: 5, volume: 27, anno: 1999,
pagine: 471 - 476
SICI:
0310-057X(199910)27:5<471:POPNAV>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
PATIENT-CONTROLLED ANALGESIA; PROPHYLACTIC ANTIEMETIC THERAPY; GYNECOLOGICAL SURGERY; DOUBLE-BLIND; DROPERIDOL; EFFICACY; METOCLOPRAMIDE; PLACEBO; EMESIS;
Keywords:
surgery : gynaecological, laparotomy; analgesia : patient-controlled, morphine; antiemetic : tropisetron, ondansetron;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Tsui, SL Queen Mary Hosp, Dept Anaesthesiol, Div Pain Management, 102 Pokfulam Rd, Pokfulam, Hong Kong Queen Mary Hosp 102 Pokfulam Rd Pokfulam HongKong m, Hong Kong
Citazione:
S.L. Tsui et al., "Prevention of postoperative nausea and vomiting in gynaecological laparotomies: A comparison of tropisetron and ondansetron", ANAESTH I C, 27(5), 1999, pp. 471-476

Abstract

In a randomized double-blind study, the antiemetic efficacy of a single bolus of tropisetron 5 mg (group T; 37 patients), ondansetron 4 mg (group O, 39 patients) or saline (group C, 45 patients) given at induction was compared in a: homogeneous group of 121 patients undergoing gynaecological laparotomy and receiving postoperative patient-controlled intravenous morphine for 24 to 48 hours. Fewer group T and group O patients developed severe nausea compared to group C (P < 0.01, Log rank test in Kaplan-Meier analysis). Group T patients also had lower nausea scores than group O at 8 to 16h (P < 0.05). The overall incidences of severe nausea in groups T: O, and C were 5.4%, 17.9%, and 44.4% respectively (P < 0.001, group T vs group C; P < 0.05group O vs group C). In conclusion, the 5-hydroxytryptamine(3) receptor antagonists tropisetron and ondansetron were superior to placebo in preventing PONV.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 13:39:50