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Titolo:
Compounds containing cytosolic choline in the basal ganglia: A potential biological marker of true drug response to fluoxetine
Autore:
Sonawalla, SB; Renshaw, PF; Moore, CM; Alpert, JE; Nierenberg, AA; Rosenbaum, JF; Fava, M;
Indirizzi:
Harvard Univ, Dept Psychiat, Massachusetts Gen Hosp, Sch Med,Depress Clin & Res Program, Boston, MA 02114 USA Harvard Univ Boston MA USA 02114 Clin & Res Program, Boston, MA 02114 USA Harvard Univ, McLean Hosp, Sch Med, McLean Brain Imaging Ctr, Belmont, MA 02178 USA Harvard Univ Belmont MA USA 02178 rain Imaging Ctr, Belmont, MA 02178 USA
Titolo Testata:
AMERICAN JOURNAL OF PSYCHIATRY
fascicolo: 10, volume: 156, anno: 1999,
pagine: 1638 - 1640
SICI:
0002-953X(199910)156:10<1638:CCCCIT>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-BRAIN; SPECTROSCOPY; DEPRESSION; PATTERN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Sonawalla, SB Harvard Univ, Dept Psychiat, Massachusetts Gen Hosp, Sch Med,Depress Clin & Res Program, WACC 812,15 Parkman St, Boston, MA 02114 USA Harvard Univ WACC 812,15 Parkman St Boston MA USA 02114 USA
Citazione:
S.B. Sonawalla et al., "Compounds containing cytosolic choline in the basal ganglia: A potential biological marker of true drug response to fluoxetine", AM J PSYCHI, 156(10), 1999, pp. 1638-1640

Abstract

Objective: Studies have identified two types of antidepressant response: true drug response and placebo pattern response. This study examined the relationship between true drug response and choline-creatine ratios in the basal ganglia of depressed patients treated with fluoxetine. Method: The authors evaluated drug-free outpatients with major depression before (N=41) and after (N=15) 8 weeks of fluoxetine treatment, 20 mg/day, by using proton magnetic resonance spectroscopy. Results: There was a significant difference in the degree of change from baseline to week 8 in choline-creatine ratios between the true drug response group (N=8) and the placebo pattern response/nonresponse group (N=7); the true drug response patients had a 20% increase in choline-creatine ratios, and the placebo pattern response/nonresponse patients had a 12% decrease in choline-creatine ratios. Conclusions: These data suggest that true drug response to fluoxetine treatment in depression may be associated with an increase in choline-creatine ratios in the basal ganglia.

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Documento generato il 20/09/20 alle ore 20:18:26