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Titolo:
SINE-R.C2 (a homo sapiens specific retroposon) is homologous to cDNA from postmortem brain in schizophrenia and to two loci in the Xq21.3/Yp flock linked to handedness and psychosis
Autore:
Kim, HS; Wadekar, RV; Takenaka, O; Winstanley, C; Mitsunaga, F; Kageyama, T; Hyun, BH; Crow, TJ;
Indirizzi:
Univ Oxford, Warneford Hosp, Dept Psychiat, POWIC, Oxford OX3 7JX, EnglandUniv Oxford Oxford England OX3 7JX chiat, POWIC, Oxford OX3 7JX, England Kyoto Univ, Primate Res Inst, Dept Cellular & Mol Biol, Inuyama, Aichi 484, Japan Kyoto Univ Inuyama Aichi Japan 484 & Mol Biol, Inuyama, Aichi 484, Japan Univ Oxford, Dept Psychol & Physiol, Oxford, England Univ Oxford Oxford England ord, Dept Psychol & Physiol, Oxford, England Genet Resources Ctr, Korea Res Inst Biosci & Biotechnol, Taejon, South Korea Genet Resources Ctr Taejon South Korea Biotechnol, Taejon, South Korea
Titolo Testata:
AMERICAN JOURNAL OF MEDICAL GENETICS
fascicolo: 5, volume: 88, anno: 1999,
pagine: 560 - 566
SICI:
0148-7299(19991015)88:5<560:S(HSSR>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL ASYMMETRY; SEX-CHROMOSOMES; HUMAN GENOME; RETROTRANSPOSONS; EVOLUTION; GENE; RETROVIRUSES; INDIVIDUALS; SEQUENCES; FEATURES;
Keywords:
retroposon; SINE-R.C2; schizophrenia; Xq21.3/Yp block; psychosis; primate;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Crow, TJ Univ Oxford, Warneford Hosp, Dept Psychiat, POWIC, Oxford OX3 7JX, England Univ Oxford Oxford England OX3 7JX WIC, Oxford OX3 7JX, England
Citazione:
H.S. Kim et al., "SINE-R.C2 (a homo sapiens specific retroposon) is homologous to cDNA from postmortem brain in schizophrenia and to two loci in the Xq21.3/Yp flock linked to handedness and psychosis", AM J MED G, 88(5), 1999, pp. 560-566

Abstract

We investigated the retroviral/retroposon hypothesis of schizophrenia by generating sequences with PCR primers based on a retroviral sequence recovered by Yee et al, [1998: Schizophr Res 29:92] from a cDNA library from postmortem brain tissue from an individual with psychosis in a genomic region (Xq21.3) that has been tentatively linked to schizophrenia and schizoaffective disorder by Laval et al, [1998: Am. J. Med. Genet, (Neuropsychiatr. Genet,) 81:420-427], Within the block of homology with Yp that was generated by a transposition between the chimpanzee and Homo sapiens we find two sequences, HS307 and HS408, with a high degree of homology to but not identity with the schizophrenic brain cDNA, The closest match of these three sequences is to a family of retroposons, that has evolved from the HERV-K family of endogenous retroviruses, some members of which (e.g., SINE-R.C2) appear to be specific to the human genome. This element has been reported as a cause of Fukuyama-type muscular dystrophy [Kobayashi et al,, 1998: Nature 394:388-392]. Such retroposons, as agents of change in the human genome, provide a strategy for investigating pathogenesis. On account of their genomic location in a region that has been subject to change in the course of hominid evolution, and that may have a relationship to psychosis and/or cerebral asymmetry, we conclude that these particular insertions deserve further investigation. (C) 1999 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 06:14:23