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Titolo:
Early onset of breast carcinoma in African American women with poor prognostic factors
Autore:
Aziz, H; Hussain, F; Sohn, C; Mediavillo, R; Saitta, A; Hussain, A; Brandys, M; Homel, P; Rotman, M;
Indirizzi:
SUNY Hlth Sci Ctr, Dept Radiat Oncol, Brooklyn, NY 11203 USA SUNY Hlth SciCtr Brooklyn NY USA 11203 iat Oncol, Brooklyn, NY 11203 USA SUNY Hlth Sci Ctr, Dept Family Practice, Brooklyn, NY 11203 USA SUNY Hlth Sci Ctr Brooklyn NY USA 11203 Practice, Brooklyn, NY 11203 USA SUNY Hlth Sci Ctr, Sci Acad Comp Ctr, Brooklyn, NY 11203 USA SUNY Hlth SciCtr Brooklyn NY USA 11203 Comp Ctr, Brooklyn, NY 11203 USA
Titolo Testata:
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS
fascicolo: 5, volume: 22, anno: 1999,
pagine: 436 - 440
SICI:
0277-3732(199910)22:5<436:EOOBCI>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
CANCER-PATIENTS; WHITE WOMEN; NATIONAL SURVEY; UNITED-STATES; SURVIVAL; BLACK; RACE; SURGEONS; COLLEGE; RISK;
Keywords:
carcinoma of breast; age; race; African American;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Aziz, H SUNY Hlth Sci Ctr, Dept Radiat Oncol, 450 Clarkson Ave,Box 1211, Brooklyn,NY 11203 USA SUNY Hlth Sci Ctr 450 Clarkson Ave,Box 1211 Brooklyn NY USA 11203
Citazione:
H. Aziz et al., "Early onset of breast carcinoma in African American women with poor prognostic factors", AM J CL ONC, 22(5), 1999, pp. 436-440

Abstract

The purpose of this study was to determine prognostic significance of age and race as independent variables and to see role of age at the onset of breast carcinoma. A retrospective study was conducted of African American andwhite women with breast cancer treated at SUNY-Health Science Center Brooklyn and Kings County Hospital Center from 1983 to 1993. The objective was to analyze the differences in patterns of disease onset, as related to age and prognostic factors. A total of 738 patients were analyzed for race-adjusted comparison of stage, grade, disease-free survival, and median survival. Age at the time of diagnosis was analyzed to conduct age-specific comparisons of African American (AA) and white patients. The multivariate analysis indicated that AA women develop breast cancer 10 years earlier than white women (p = 0.00001). Corrected by stage and grade, i.e., chi(2) test for stage-by-stage and grade-by-grade analysis has revealed that the AA women present with higher stage (p = 0.009), increased number of positive nodes (p = 0.00007), and more estrogen receptor/progesterone receptor-negative tumors (p = 0.005). Further studies are required to probe into the etiologic possibilities of this significant difference. The important contributing factorscould be hormonal, genetic, environmental, and socioeconomic. Obesity and dietary factors also need to be evaluated, Further studies to explore genetic susceptibility by ploidy is recommended to explain this significant difference. We conclude that the onset of breast cancer among AA women occurs at a significantly younger age than in white women, and their prognostic factors are poorer.

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Documento generato il 11/07/20 alle ore 09:36:52