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Titolo:
Characterization of subtype A HIV-1 from Africa by full genome sequencing
Autore:
Carr, JK; Laukkanen, T; Salminen, MO; Albert, J; Alaeus, A; Kim, B; Sanders-Buell, E; Birx, DL; McCutchan, FE;
Indirizzi:
Henry M Jackson Fdn, Rockville, MD USA Henry M Jackson Fdn Rockville MD USA ry M Jackson Fdn, Rockville, MD USA Natl Publ Hlth Inst, Helsinki, Finland Natl Publ Hlth Inst Helsinki Finland Publ Hlth Inst, Helsinki, Finland Karolinska Inst, Swedish Inst Infect Dis Control, Stockholm, Sweden Karolinska Inst Stockholm Sweden Infect Dis Control, Stockholm, Sweden Walter Reed Army Inst Res, Div Retrovirol, Rockville, MD USA Walter Reed Army Inst Res Rockville MD USA Retrovirol, Rockville, MD USA
Titolo Testata:
AIDS
fascicolo: 14, volume: 13, anno: 1999,
pagine: 1819 - 1826
SICI:
0269-9370(19991001)13:14<1819:COSAHF>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHYLOGENETIC ANALYSIS; GENETIC DIVERSITY; TYPE-1; RECOMBINANTS; CONFIDENCE; THAILAND; ORIGIN;
Keywords:
HIV; Africa; molecular epidemiology; viral origins; recombination;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Carr, JK 1 Taft Court, Rockville, MD 20850 USA 1 Taft Court Rockville MD USA 20850 urt, Rockville, MD 20850 USA
Citazione:
J.K. Carr et al., "Characterization of subtype A HIV-1 from Africa by full genome sequencing", AIDS, 13(14), 1999, pp. 1819-1826

Abstract

Objective: To improve our understanding of the genetic complexity of HIV-1subtype A by increasing the number of subtype A isolates that have been sequenced in their entirety. Methods: Nine HIV-1-seropositive patients from Africa living in Sweden contributed peripheral blood mononuclear cells (PBMC) for this study. Sequencing of the C2-V3 region of env had shown them to be subtype A. DNA from virus cultures was used for the amplification of virtually full-length proviralsequences, and the resulting fragment was sequenced. Results: Six of the nine viral isolates were subtype A throughout the genome, or non-recombinant and all of these were from east Africa. One virus from the ivory Coast had the AG(IbNG) genetic form, a recombinant form commonin west Africa. Two of the isolates were novel recombinants: one was an A/C recombinant and the other was A/D. Analysis of gag reveals three subclusters within the A subtype: one containing the AG(IbNC) subtype viruses, one containing the AE(CM240) viruses and one containing the non-recombinant A viruses. These genetic clusters have different geographical distributions inAfrica. Conclusion: The prevailing view of HIV-1 subtype A forming a uniform band across the center of sub-Saharan Africa needs revision. In all probability,the most common subtype in west Africa and west central Africa is the AG recombinant, AG(IbNC), whereas in east central Africa it is the non-recombinant subtype A. (C) 1999 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 18:04:21