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Titolo:
Conformational analysis of a novel cyclic enkephalin analogue using NMR and EDMC calculations
Autore:
Sidor, M; Wojcik, J; Pawlak, D; Izdebski, J;
Indirizzi:
Univ Warsaw, Dept Chem, Lab Peptides, PL-02093 Warsaw, Poland Univ WarsawWarsaw Poland PL-02093 Lab Peptides, PL-02093 Warsaw, Poland Polish Acad Sci, Inst Biochem & Biophys, Lab Biol NMR, PL-02106 Warsaw, Poland Polish Acad Sci Warsaw Poland PL-02106 Biol NMR, PL-02106 Warsaw, Poland
Titolo Testata:
ACTA BIOCHIMICA POLONICA
fascicolo: 3, volume: 46, anno: 1999,
pagine: 641 - 650
SICI:
0001-527X(1999)46:3<641:CAOANC>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
MULTIPLE-MINIMA PROBLEM; DRIVEN MONTE-CARLO; CORRELATION SPECTROSCOPY; CHEMICAL-SHIFTS; SIDE-CHAIN; POLYPEPTIDES; SENSITIVITY; SPECIFICITY; INVITRO; BRIDGE;
Keywords:
cyclic enkephalin; cyclo(N-epsilon,N-epsilon ' -carbonyl-D-Lys(2),Lys(5))enkephalinamide; conformation; EDMC; NMR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Wojcik, J Univ Warsaw, Dept Chem, Lab Peptides, L Pasteura 1, PL-02093 Warsaw, Poland Univ Warsaw L Pasteura 1 Warsaw Poland PL-02093 Warsaw, Poland
Citazione:
M. Sidor et al., "Conformational analysis of a novel cyclic enkephalin analogue using NMR and EDMC calculations", ACT BIOCH P, 46(3), 1999, pp. 641-650

Abstract

Conformational space of a novel cyclic enkephalin analogue, cyclo(N-epsilon,N-epsilon'-carbonyl-D-Lys(2),Lys(5))enkephalinamide, was exhaustively examined. A large number of conformations was selected and clustered into families on the basis of their structure and energy. For representative conformations ROESY spectra were generated and their linear combination was fittedto the spectra measured in water and Me2SO-d(6). This procedure yielded anensemble of most populated conformations of the peptide in the two solvents.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/10/20 alle ore 15:30:59