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Titolo:
The potential roles of estrogens in regulating Leydig cell development andfunction: A review
Autore:
Abney, TO;
Indirizzi:
Med Coll Georgia, Dept Physiol & Endocrinol, Augusta, GA 30912 USA Med Coll Georgia Augusta GA USA 30912 & Endocrinol, Augusta, GA 30912 USA
Titolo Testata:
STEROIDS
fascicolo: 9, volume: 64, anno: 1999,
pagine: 610 - 617
SICI:
0039-128X(199909)64:9<610:TPROEI>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
LUTEINIZING-HORMONE RECEPTORS; HUMAN CHORIONIC-GONADOTROPIN; ETHANE DIMETHANE SULFONATE; TREATED MATURE RAT; IN-UTERO EXPOSURE; TESTOSTERONE PRODUCTION; TESTICULAR DESCENT; HYPOPHYSECTOMIZED RATS; SELECTIVE DESTRUCTION; REPRODUCTIVE FUNCTION;
Keywords:
Leydig cells; estradiol; estrogen receptor; precursor cells; proliferation; cryptorchidism; desensitization; ethane dimethylsulfonate (EDS); steroidogenesis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
104
Recensione:
Indirizzi per estratti:
Indirizzo: Abney, TO Med Coll Georgia, Dept Physiol & Endocrinol, Augusta, GA 30912 USA Med Coll Georgia Augusta GA USA 30912 ol, Augusta, GA 30912 USA
Citazione:
T.O. Abney, "The potential roles of estrogens in regulating Leydig cell development andfunction: A review", STEROIDS, 64(9), 1999, pp. 610-617

Abstract

It is generally agreed that estrogens, principally estradiol-17 beta, are synthesized by and act in the testis of mammals, including humans. The siteof estradiol synthesis in the testis is generally believed to begin in theSertoli fell and switch to the Leydig cell during neonatal development where a gonadotropin-regulated aromatase is present. Numerous studies suggest that the primary target cell of estradiol in the testis at all ages is the Leydig cell. In fact, the Leydig cell is known to possess an estrogen receptor that binds estradiol in the classic manner. The mechanism of estradiol action and the role of its receptor in the testis, however, remain unresolved. In Leydig tells, estradiol appears to induce several alterations that are dependent in large part on the developmental stage of the Leydig cell. In the fetal and neonatal testes, estradiol appears to block the ontogenic development of Leydig cells from precursor cells. There is also evidence that estradiol similarly blocks the regeneration of Leydig cells in the testisof mature, ethane dimethylsulfonate-treated animals. Evidence indicates that the precursor cell possesses high levels of estrogen receptors relative to that of the Leydig cell. It is postulated that estradiol is a paracrine factor involved in regulating the interstitial population of Leydig cells. Evidence also indicates that estradiol acts directly in the mature testis to block androgen production. It appears to do so by inhibiting the activities of several steroidogenic enzymes involved in testosterone synthesis. Although the more conventional receptor-mediated mode of action is feasible, several studies have suggested that this action might entail direct competitive inhibition of key steroidogenic enzymes by estradiol. In summary, the net biologic effect of estradiol in the testis appears to be inhibition of androgen production, either by limiting development and growth of the Leydigcell population or through direct action in the Leydig cell. (C) 1999 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 19:39:41