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Titolo:
Effect of immunomodulators on bleomycin-induced lung injury
Autore:
Kremer, S; Breuer, R; Lossos, IS; Berkman, N; Christensen, TG; Connor, MW; Goldstein, RH; Or, R;
Indirizzi:
Hadassah Univ Hosp, Inst Pulm, Lung Cellular & Mol Biol Lab, IL-91120 Jerusalem, Israel Hadassah Univ Hosp Jerusalem Israel IL-91120 IL-91120 Jerusalem, Israel Hadassah Univ Hosp, Dept Bone Marrow Transplant, IL-91120 Jerusalem, Israel Hadassah Univ Hosp Jerusalem Israel IL-91120 IL-91120 Jerusalem, Israel Hebrew Univ Jerusalem, Hadassah Med Sch, IL-91010 Jerusalem, Israel HebrewUniv Jerusalem Jerusalem Israel IL-91010 -91010 Jerusalem, Israel Boston Univ, Sch Med, Mallory Inst Pathol, Dept Pathol, Boston, MA 02215 USA Boston Univ Boston MA USA 02215 Pathol, Dept Pathol, Boston, MA 02215 USA Boston Univ, Sch Med, Ctr Pulm, Boston, MA 02215 USA Boston Univ Boston MA USA 02215 , Sch Med, Ctr Pulm, Boston, MA 02215 USA
Titolo Testata:
RESPIRATION
fascicolo: 5, volume: 66, anno: 1999,
pagine: 455 - 462
SICI:
0025-7931(199909/10)66:5<455:EOIOBL>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED PULMONARY FIBROSIS; PHOSPHODIESTERASE INHIBITOR PENTOXIFYLLINE; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; BRONCHOALVEOLAR LAVAGE FLUID; LYMPHOKINE PRODUCTION; MEDIATED ACTIVATION; GENE-EXPRESSION; IN-VITRO; LINOMIDE; INTERLEUKIN-4;
Keywords:
bleomycin; linomide; pentoxifylline; lung; mice;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Breuer, R Hadassah Univ Hosp, Inst Pulm, Lung Cellular & Mol Biol Lab, POB12000, IL-91120 Jerusalem, Israel Hadassah Univ Hosp POB 12000 Jerusalem Israel IL-91120 , Israel
Citazione:
S. Kremer et al., "Effect of immunomodulators on bleomycin-induced lung injury", RESPIRATION, 66(5), 1999, pp. 455-462

Abstract

Background: The role of lymphocytes and their subpopulations in lung fibrosis is as yet unclear. Objective: To define the role of immunomodulation inbleomycin-induced inflammatory fibrotic lung injury, by testing the effectof two known Th1 inhibitors: linomide and pentoxifylline. Methods: C57BL/6mice were treated by a single intratracheal instillation of 0.06 mg bleomycin in 0.01 ml saline or saline alone. Treatment groups included: (1) intratracheal bleomycin and daily treatment with linomide or pentoxifylline; (2)intratracheal bleomycin and daily water; (3) intratracheal saline and daily linomide or pentoxifylline; (4) intratracheal saline and daily water. Linomide and pentoxifylline were available per os in the drinking water from 1day prior to intratracheal instillation. Animals were studied 14 days after intratracheal instillation. Lung injury was evaluated by total and differential cell count in bronchoalveolar lavage fluid, by a semiquantitative morphological index of lung injury and a quantitative image analysis of cellularity, fibrosis fraction and alveolar wall area fraction, and by biochemical analysis of lung hydroxyproline content. Results: Linomide or pentoxifylline did not cause any lung injury in saline-treated control mice. Overt signs of lung injury were apparent in bleomycin-treated mice. These changes were not affected by daily treatment with linomide or pentoxifylline, which were given in the highest tolerable dose. Conclusion: This study does not support the use of linomide or pentoxifylline to prevent or ameliorate lung fibrosis and may suggest that drug-induced differentiation of T lymphocytesinto Th1/th2 subpopulations does not affect the evolution of bleomycin-induced lung injury.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 19:39:36