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Titolo:
Hepatic fibrogenic activity in chronic alcoholic pancreatitis
Autore:
Valderrama, R; Navarro, S; Bruguera, M; Lopez, JM; Caballeria, J; Bianchi, L; Perez-Ayuso, RM; Gimenez, A; Adrian, MJ; Pares, A; Fernandez-Cruz, L; Teres, J;
Indirizzi:
Univ Barcelona, Gastroenterol Serv, Hosp Clin, Barcelona 08036, Spain UnivBarcelona Barcelona Spain 08036 , Hosp Clin, Barcelona 08036, Spain Univ Barcelona, Liver Unit, Hosp Clin, Barcelona, Spain Univ Barcelona Barcelona Spain Liver Unit, Hosp Clin, Barcelona, Spain Univ Barcelona, Serv Radiol, Hosp Clin, Barcelona, Spain Univ Barcelona Barcelona Spain Serv Radiol, Hosp Clin, Barcelona, Spain Univ Barcelona, Dept Surg, Hosp Clin, Inst Malalties Digest, Barcelona, Spain Univ Barcelona Barcelona Spain Inst Malalties Digest, Barcelona, Spain Univ Barcelona, Dept Med, Hosp Clin, Inst Invest Biomed August Pi & Sunyer, Barcelona, Spain Univ Barcelona Barcelona Spain med August Pi & Sunyer, Barcelona, Spain
Titolo Testata:
PANCREAS
fascicolo: 3, volume: 19, anno: 1999,
pagine: 276 - 280
SICI:
0885-3177(199910)19:3<276:HFAICA>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
BILE-DUCT STENOSIS; LIVER-DISEASE; SPECTRUM;
Keywords:
chronic alcoholic pancreatitis; fibrosis; fibrogenesis; cholestasis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Navarro, S Univ Barcelona, Gastroenterol Serv, Hosp Clin, Villarroel 170, Barcelona 08036, Spain Univ Barcelona Villarroel 170 Barcelona Spain 08036036, Spain
Citazione:
R. Valderrama et al., "Hepatic fibrogenic activity in chronic alcoholic pancreatitis", PANCREAS, 19(3), 1999, pp. 276-280

Abstract

The prevalence and the mechanisms of hepatic fibrosis in chronic alcoholicpancreatitis remain uncertain. The aim of this study was to investigate the fibrogenic activity of the liver in patients with chronic pancreatitis and its relation with either the alcohol or cholestasis. Liver biopsies were obtained from 16 patients with chronic pancreatitis at the time of surgery and from 10 organ donors. Samples were processed for histologic examinationto assess the presence and extent of fibrosis, inflammatory reactions, andcholestasis- and alcohol related lesions. In other samples, the collagen content was measured by morphometry, and prolylhydroxylase activity was determined. Liver-function tests, ultrasonography, and endoscopic retrograde cholangiopancreatography, were performed before surgery in all the patients. Of patients with chronic pancreatitis, 75% had significantly greater hepatic fibrosis and prolylhydroxylase activity than the control group. Moreover,prolylhydroxylase activity in patients with chronic pancreatitis was higher in those with cholestasis or partial obstruction of the common bile duct than in those without cholestasis or partial obstruction of the common bileduct. Both the fibrogenic activity and the collagen content in the livers of patients with chronic alcoholic pancreatitis are significantly increased, even in those without histologic lesions, and these alterations may be secondary to a partial occlusion of the common bile duct.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 15:42:04