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Titolo:
Characterisation of Ga-67(3+) complexes of triaza macrocyclic ligands: Biodistribution and clearance studies
Autore:
Prata, MIM; Santos, AC; Geraldes, CFGC; de Lima, JJP;
Indirizzi:
Univ Coimbra, Fac Ciencias & Tecnol, Dept Bioquim, P-3000 Coimbra, Portugal Univ Coimbra Coimbra Portugal P-3000 t Bioquim, P-3000 Coimbra, Portugal Univ Coimbra, Fac Med, Serv Biofis & Biomatemat, Coimbra, Portugal Univ Coimbra Coimbra Portugal rv Biofis & Biomatemat, Coimbra, Portugal Univ Coimbra, Ctr Neurociencias, Coimbra, Portugal Univ Coimbra Coimbra Portugal bra, Ctr Neurociencias, Coimbra, Portugal
Titolo Testata:
NUCLEAR MEDICINE AND BIOLOGY
fascicolo: 6, volume: 26, anno: 1999,
pagine: 707 - 710
SICI:
0969-8051(199908)26:6<707:COGCOT>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
RADIOPHARMACEUTICALS; GALLIUM; STABILITIES; TRANSFERRIN; IN(III); GA(III); FE(III); BINDING; INDIUM;
Keywords:
radiopharmaceutical; gamma imaging; biodistribution; Ga-67(3+) complexes; triazamacrocycles;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Geraldes, CFGC Univ Coimbra, Fac Ciencias & Tecnol, Dept Bioquim, Apartado3126, P-3000 Coimbra, Portugal Univ Coimbra Apartado 3126 Coimbra Portugal P-3000 ortugal
Citazione:
M.I.M. Prata et al., "Characterisation of Ga-67(3+) complexes of triaza macrocyclic ligands: Biodistribution and clearance studies", NUCL MED BI, 26(6), 1999, pp. 707-710

Abstract

The Ga-67(3+) complexes of three triazamacrocycles, 1,4,7-triazacyclononane-N,N',N"-triacetic acid (NOTA), its phosphonate analog 1,4,7-triazacyclononane-N,N',N"-tris(methylenephosphonic) acid (NOTP), and the monoethyl esterof NOTP, 1,4,7-triazacyclononane-N,N',N"-tris (methylenephosphonate-monoethylester) (NOTPME) were studied for possible use as radiopharmaceuticals. Biodistribution studies and gamma imaging were performed in Wistar rats. Thepresent results demonstrated that all the macrocyclic complexes studied display renal clearance and are almost completely eliminated within 24 h. The[Ga-67](NOTP)(3-) chelate, with a large negative charge, has a considerably slower uptake and elimination by the kidneys than the neutral [Ga-67](NOTA) and [Ga-67](NOTPME) chelates. We have thus demonstrated a charge-clearance relationship for a series of stable and well characterized complexes. The high stability and rapid renal excretion properties displayed by the NOTAand NOTPME chelates support their possible application as imaging agents for kidney structural and functional studies. NUCL MED BIOL 26;6:707-710, 1999. (C) 1999 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 14:24:50