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Titolo:
In vivo binding of [C-11]nemonapride to sigma receptors in the cortex and cerebellum
Autore:
Ishiwata, K; Senda, M;
Indirizzi:
Tokyo Metropolitan Inst Gerontol, Positron Med Ctr, Itabashi Ku, Tokyo 1730022, Japan Tokyo Metropolitan Inst Gerontol Tokyo Japan 1730022 okyo 1730022, Japan
Titolo Testata:
NUCLEAR MEDICINE AND BIOLOGY
fascicolo: 6, volume: 26, anno: 1999,
pagine: 627 - 631
SICI:
0969-8051(199908)26:6<627:IVBO[T>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
H-3 NEMONAPRIDE BINDING; DOPAMINE D-4 RECEPTORS; D4 RECEPTORS; MOUSE-BRAIN; SCHIZOPHRENIA; YM-09151-2; PET; RACLOPRIDE; SITES; HALOPERIDOL;
Keywords:
[C-11]nemonapride; sigma receptor; in vivo; dopamine D-2-like receptor; PET;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Ishiwata, K Tokyo Metropolitan Inst Gerontol, Positron Med Ctr, Itabashi Ku, 1-1 Naka Cho, Tokyo 1730022, Japan Tokyo Metropolitan Inst Gerontol 1-1 Naka Cho Tokyo Japan 1730022
Citazione:
K. Ishiwata e M. Senda, "In vivo binding of [C-11]nemonapride to sigma receptors in the cortex and cerebellum", NUCL MED BI, 26(6), 1999, pp. 627-631

Abstract

Radiolabeled nemonapride (NEM, YM-09151-2) is widely used as a representative dopamine D-2,-like receptor ligand in pharmacological and neurological studies, and C-11-labeled analog ([C-11]NEM) has been developed for positron emission tomography (PET) studies. The aim of this study was to evaluate whether [C-11]NEM binds in vivo to sigma receptors. [C-11]NEM and one of six dopamine D-2-like receptor ligands or seven sigma receptor ligands were co-injected into mice, and the regional brain uptake of [C-11]NEM was measured by a tissue dissection method. The striatal uptake of [C-11]NEM was reduced by D-2-like receptor ligands, NEM, haloperidol, (+)-butaclamol, raclopride, and sulpiride, but not by a Dq receptor ligand clozapine. In the cortex and cerebellum the uptake was also reduced by D-2-like receptor ligands with affinity for sigma receptors, but not by raclopride. Although none of seven sigma receptor ligands, SA6298, N,N-dipropyl-2-[4-methoxy-3-(2-phenylethoxy)phenyl]ethylamine hydrochloride (NE-100), (+)-pentazocine, R(-)-N-(3-phenyl-1-propyl)-1-phenyl-2-aminopropane hydrochloride ([-]-PPAP), (-)-pentazocine, R(+)-3-(3-hydroxyphenyl)-N-propylpiperidin hydrochloride ([+]-3-PPP), and (+)-N-allylnormetazocine hydrochloride ([+] SKF 10047), blocked thestriatal uptake, five of them with relatively higher affinity significantly reduced the [C-11]NEM uptake by the cortex, and four of them reduced thatby the cerebellum. We concluded that [C-11]NEM binds in vivo not only to dopamine D-2-like receptors in the striatum but also to sigma receptors in other regions such as cortex and cerebellum. NUCL MED BIOL 26;6:627-631, 1999. (C) 1999 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 18:26:52