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Titolo:
Characterization of orexin-A and orexin-B in the microdissected rat brain nuclei and their contents in two obese rat models
Autore:
Mondal, MS; Nakazato, M; Date, Y; Murakami, N; Hanada, R; Sakata, T; Matsukura, S;
Indirizzi:
Miyazaki Med Coll, Dept Internal Med 3, Miyazaki 8891692, Japan Miyazaki Med Coll Miyazaki Japan 8891692 Med 3, Miyazaki 8891692, Japan Miyazaki Univ, Dept Vet Physiol, Miyazaki 8892192, Japan Miyazaki Univ Miyazaki Japan 8892192 et Physiol, Miyazaki 8892192, Japan Med Coll Oita, Dept Internal Med 1, Oita 8795593, Japan Med Coll Oita Oita Japan 8795593 ept Internal Med 1, Oita 8795593, Japan
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 1, volume: 273, anno: 1999,
pagine: 45 - 48
SICI:
0304-3940(19990924)273:1<45:COOAOI>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
HYPOTHALAMUS; RECEPTORS;
Keywords:
orexins; lateral hypothalamus; leptin; cholecystokinin; obesity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Nakazato, M Miyazaki Med Coll, Dept Internal Med 3, Miyazaki 8891692, Japan Miyazaki Med Coll Miyazaki Japan 8891692 zaki 8891692, Japan
Citazione:
M.S. Mondal et al., "Characterization of orexin-A and orexin-B in the microdissected rat brain nuclei and their contents in two obese rat models", NEUROSCI L, 273(1), 1999, pp. 45-48

Abstract

Orexin-A and orexin-B (also known as hypocretins) are newly discovered hypothalamic peptides that stimulate food intake. Using separate radioimmunoassays for these rat orexins, we determined their distributions in microdissected nuclei of the diencephalon and brainstem which have accumulations of orexin fibers. High orexin contents (orexin-A: between 250 and 350 fmol/mg protein and orexin-B: between 650 and 900 fmol/mg protein) were present in the lateral hypothalamus; ventromedial hypothalamic, paraventricular thalamic and dorsal raphe nuclei; periaqueductal central gray and locus coeruleus. Moderate orexin contents (orexin-A: between 100 and 250 fmol/mg protein and orexin-B: between 300 and 500 fmol/mg protein) were found in the median eminence; suprachiasmatic, paraventricular hypothalamic, arcuate and supraoptic nuclei; substantia nigra and the nucleus of the solitary tract. Mature orexin-A and -B peptides were the major endogenous orexin molecules in these nuclei. The orexin-A and -B contents in the brains of obese Zucker rats that have disrupted leptin receptor were significantly higher than in their lean littermates, but in Otsuka Long-Evans Tokushima Fatty rats that have disrupted cholecystokinin type-A receptor the contents were similar to thoseof the controls. The widespread orexin distributions in the nuclei of diencephalon and brainstem suggest that orexins serve as neuromodulators, neurotransmitters, or both, in a wide variety of neural networks that regulate the autonomic and neuroendocrine systems. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 13:04:00